The organization of the cone photoreceptor mosaic measured in the living human retina.
The organization of the cone photoreceptor mosaic measured in the living human retina.
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DOI：
10.1016/j.visres.2016.06.006
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发表时间：
2017-03
期刊：
影响因子：
1.8
通讯作者：
Burns SA
中科院分区：
文献类型：
--
作者：
Sawides L;de Castro A;Burns SA
视锥细胞代表获取视觉信息的初始基本采样步骤。虽然自适应光学的最新进展已经对活人视网膜中锥体感光器的堆积密度和间距提供了越来越精确的估计，但除了六边形堆积的趋势之外，对局部锥体排列知之甚少。我们分析了 10 名正常受试者数据中的视锥细胞镶嵌情况。应用一种技术来计算局部平均锥形镶嵌结构，这使我们能够确定局部区域的六边形、间距和方向。使用视锥细胞间距估计，我们发现随着视网膜偏心率，视锥细胞密度预期会降低，并且沿水平子午线的密度高于垂直子午线。取向分析揭示了六角形堆积的局部锥体间距不对称，锥体沿水平方向具有较大的局部间距。这种水平/垂直不对称性在上子午线偏心率大于 2 度、下子午线偏心率大于 2.5 度时发生改变。对视网膜中央 1.4° 的六边形方向的分析表明，方向有局部一致的趋势，方向斑块由 35 到 240 个视锥细胞组成。
The cone photoreceptors represent the initial fundamental sampling step in the acquisition of visual information. While recent advances in adaptive optics have provided increasingly precise estimates of the packing density and spacing of the cone photoreceptors in the living human retina, little is known about the local cone arrangement beyond a tendency towards hexagonal packing. We analyzed the cone mosaic in data from 10 normal subjects. A technique was applied to calculate the local average cone mosaic structure which allowed us to determine the hexagonality, spacing and orientation of local regions. Using cone spacing estimates, we find the expected decrease in cone density with retinal eccentricity and higher densities along the horizontal meridians as opposed to the vertical meridians. Orientation analysis reveals an asymmetry in the local cone spacing of the hexagonal packing, with cones having a larger local spacing along the horizontal direction. This horizontal/vertical asymmetry is altered at eccentricities larger than 2 degrees in the superior meridian and 2.5 degrees in the inferior meridian. Analysis of hexagon orientations in the central 1.4° of the retina show a tendency for orientation to be locally coherent, with orientation patches consisting of between 35 and 240 cones.