Decreased amygdala activation during risk taking in non-dependent habitual alcohol users: A preliminary fMRI study of the stop signal task.
Decreased amygdala activation during risk taking in non-dependent habitual alcohol users: A preliminary fMRI study of the stop signal task.
复制标题
非依赖性习惯性饮酒者冒险时杏仁核激活减少：停止信号任务的初步功能磁共振成像研究。
DOI：
10.1080/00952990902968569
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Li,Chiang-ShanRay
中科院分区：
文献类型：
--
作者：
Yan,Peisi;Li,Chiang-ShanRay
背景和目的：习惯性饮酒是酒精依赖的先兆。有人认为，冲动控制的障碍有助于习惯性饮酒。很少有人知道与冲动控制相关的神经过程是否在非依赖性社交饮酒者中发生了改变。目前的初步研究相结合的功能磁共振成像和停止信号任务（SST），以解决这个问题。方法：我们比较了非依赖性非/轻（n = 12）和中度/重度（n = 9）的年轻成人酒精饮用者在SST中，其中他们被要求行使抑制控制在停止试验，并从事在一个速度/准确性的权衡duing试验到试验去的反应。我们以前的研究确定了抑制控制和冒险在SST的神经相关。此外，酒精依赖患者在抑制控制和冒险过程中表现出改变的大脑激活，与healhty controls .Results相比：我们发现，中度/重度饮酒者在冒险过程中杏仁核激活减少，而与非/轻度饮酒者相比，抑制控制的神经措施无区别。冒险过程中杏仁核激活的改变可能是早期习惯性饮酒的关键神经过程，也是介导向酒精依赖转变的潜在标记。
Background and Objectives: Habitual alcohol use is prodromal to alcohol dependence. It has been suggested that impairment in impulse control contributes to habitual drinking. Little is known whether neural processes associated with impulse control is altered in non-dependent social drinkers. The current preliminary study combined functional magnetic resonance imaging and the stop signal task (SST) to address this issue.Methods: We compared non-dependent non/light (n = 12) and moderate/heavy (n = 9) young adult alchol drinkers in a SST, in which they were required to exercise inhibitory control during the stop trials and were engaged in a speed/accuracy trade-off duing trial-to-trial go responses. Our previous studies identified neural correlates of inhibitory control and risk taking during the SST . Furthermore, alcohol dependent patients showed altered brain activation both during inhibitory control and risk taking, compared to healhty controls .Results: We showed that moderate/heavy alcohol drinkers were decreased in amygdala activation during risk taking, while indistinguishable in neural measures of inhibitory control, when compared to non/light drinkers.Conclusions and Significance: Altered amygdala activation during risk taking may be a key neural process underlying early habitual alcohol use and a potential marker mediating transition to alcohol dependence.