Bile salts stimulate recruitment of IpaB to the Shigella flexneli surface, where it colocalizes with IpaD at the tip of the type III secretion needle
Bile salts stimulate recruitment of IpaB to the Shigella flexneli surface, where it colocalizes with IpaD at the tip of the type III secretion needle
复制标题
DOI：
10.1128/iai.01599-06
复制
发表时间：
2007-05-01
影响因子：
3.1
通讯作者：
Picking, William D.
中科院分区：
文献类型：
--
作者：
Olive, Andrew J.;Kenjale, Roma;Picking, William D.
Shigella flexneri uses its type III secretion apparatus (TTSA) to deliver invasins into human cells. This TTSA possesses an external needle with IpaD at its tip. We now show that deoxycholate promotes the stable recruitment of IpaB to the needle tip without inducing a rapid burst of type III secretion. The maintenance of IpaB at the needle tip requires a stable association of IpaD with the Shigella surface. This is the first demonstration of a translocator protein being stably associated with the TTSA needle.
