Effect of N-Acetylcysteine on Sleep: Impacts of Sex and Time of Day.
Effect of N-Acetylcysteine on Sleep: Impacts of Sex and Time of Day.
复制标题
N-乙酰半胱氨酸对睡眠的影响：性别和时间的影响。
DOI：
10.3390/antiox12051124
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发表时间：
2023-05-19
期刊：
影响因子：
7
通讯作者：
Wisor, Jonathan P.
中科院分区：
文献类型：
--
作者：
Bushana, Priyanka N.;Schmidt, Michelle A.;Chang, Kevin M.;Vuong, Trisha;Sorg, Barbara A.;Wisor, Jonathan P.
非快速眼动睡眠(NREMS)伴随着大脑新陈代谢的下降，从而减少了作为燃料来源的葡萄糖的消耗，并减少了神经和周围组织中氧化应激的整体积累。使新陈代谢向还原氧化还原环境转变可能是睡眠的核心功能。因此，加强细胞抗氧化途径的生化操作可能会促进睡眠的这一功能。N-乙酰半胱氨酸通过作为谷胱甘肽的前体提高细胞的抗氧化能力。在小鼠中，我们观察到，在睡眠驱动力自然较高的一天中，在腹膜腔内注射N-乙酰半胱氨酸会加速睡眠的开始，并降低NREMS增量功率。此外，给予N-乙酰半胱氨酸可抑制安静清醒状态下的慢速和β脑电活动，进一步证明了抗氧化剂的疲劳诱导特性以及氧化还原平衡对与睡眠驱动相关的皮质回路特性的影响。这些结果表明，氧化还原反应与睡眠/清醒周期中皮质网络事件的动态平衡有关，说明了相对于睡眠/清醒周期，定时给予抗氧化剂的价值。本文对相关文献的系统回顾表明，在有关抗氧化剂治疗精神分裂症等脑部疾病的临床文献中，这一“时间治疗假说”并未被提及。因此，我们主张系统地研究抗氧化剂治疗相对于睡眠/清醒周期实施的时间与该抗氧化剂治疗脑部疾病的疗效之间的关系。
Non-rapid eye movement sleep (NREMS) is accompanied by a decrease in cerebral metabolism, which reduces the consumption of glucose as a fuel source and decreases the overall accumulation of oxidative stress in neural and peripheral tissues. Enabling this metabolic shift towards a reductive redox environment may be a central function of sleep. Therefore, biochemical manipulations that potentiate cellular antioxidant pathways may facilitate this function of sleep. N-acetylcysteine increases cellular antioxidant capacity by serving as a precursor to glutathione. In mice, we observed that intraperitoneal administration of N-acetylcysteine at a time of day when sleep drive is naturally high accelerated the onset of sleep and reduced NREMS delta power. Additionally, N-acetylcysteine administration suppressed slow and beta electroencephalographic (EEG) activities during quiet wake, further demonstrating the fatigue-inducing properties of antioxidants and the impact of redox balance on cortical circuit properties related to sleep drive. These results implicate redox reactions in the homeostatic dynamics of cortical network events across sleep/wake cycles, illustrating the value of timing antioxidant administration relative to sleep/wake cycles. A systematic review of the relevant literature, summarized herein, indicates that this “chronotherapeutic hypothesis” is unaddressed within the clinical literature on antioxidant therapy for brain disorders such as schizophrenia. We, therefore, advocate for studies that systematically address the relationship between the time of day at which an antioxidant therapy is administered relative to sleep/wake cycles and the therapeutic benefit of that antioxidant treatment in brain disorders.
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影响因子：
2.9
作者：
HONDA, K;KOMODA, Y;INOUE, S
通讯作者：
INOUE, S
影响因子：
3.7
作者：
Clark J;Clore EL;Zheng K;Adame A;Masliah E;Simon DK
通讯作者：
Simon DK
影响因子：
9.8
作者：
Hill VM;O'Connor RM;Sissoko GB;Irobunda IS;Leong S;Canman JC;Stavropoulos N;Shirasu-Hiza M
通讯作者：
Shirasu-Hiza M
影响因子：
3
作者：
Durieux AM;Fernandes C;Murphy D;Labouesse MA;Giovanoli S;Meyer U;Li Q;So PW;McAlonan G
通讯作者：
McAlonan G
影响因子：
5.6
作者：
Harkness, John H.;Bushana, Priyanka N.;Wisor, Jonathan P.
通讯作者：
Wisor, Jonathan P.