ASSOCIATION OF ASTHMA WITH SERUM IGE LEVELS AND SKIN-TEST REACTIVITY TO ALLERGENS
ASSOCIATION OF ASTHMA WITH SERUM IGE LEVELS AND SKIN-TEST REACTIVITY TO ALLERGENS
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DOI：
10.1056/nejm198902023200502
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发表时间：
1989-02-02
影响因子：
158.5
通讯作者：
CLINE, MG
中科院分区：
文献类型：
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作者：
BURROWS, B;MARTINEZ, FD;CLINE, MG
在一项普通人群研究中，我们调查了2657名受试者自我报告的哮喘或过敏性鼻炎与血清IgE水平和皮肤试验对过敏原的反应性的关系。无论受试者是否有特应性或其所属年龄组，哮喘患病率均与按年龄和性别标准化的血清IgE水平密切相关（P<0.0001），且177例按年龄和性别IgE水平最低的受试者（>比平均值低1.46 SD）均未出现哮喘。在我们控制了可能的混杂因素和对皮肤试验的反应程度后，对数比值比随血清IgE水平线性增加。相反，变应性鼻炎似乎主要与皮肤试验对常见空气过敏原的反应有关，与血清IgE水平无关。我们得出结论，哮喘几乎总是与某种类型的ige相关反应有关，因此具有过敏基础，尽管并非所有引起哮喘的过敏刺激似乎都包括在我们用来评估特应性状态的常见空气过敏原中。这些发现挑战了所谓过敏性（“外在”）和非过敏性（“内在”）哮喘之间存在基本差异的概念。[J] .中华医学杂志，1989;32(3):771 - 771。
We investigated the association of self-reported asthma or allergic rhinitis with serum IgE levels and skin-test reactivity to allergens in 2657 subjects in a general-population study. Regardless of the subjects' status with respect to atopy or their age group, the prevalence of asthma was closely related to the serum IgE level standardized for age and sex (P<0.0001), and no asthma was present in the 177 subjects with the lowest IgE levels for their age and sex (>1.46 SD below the mean). The log odds ratio increased linearly with the serum IgE level after we controlled for possible confounders and the degree of reactivity to skin tests. In contrast, allergic rhinitis appeared to be associated primarily with skin-test reactions to common aeroallergens, independently of the serum IgE level.We conclude that asthma is almost always associated with some type of IgE-related reaction and therefore has an allergic basis, although not all the allergic stimuli that cause asthma appear to have been included in the battery of common aeroallergens we used to assess atopic status. These findings challenge the concept that there are basic differences between so-called allergic ("extrinsic") and nonallergic ("intrinsic") forms of asthma. (N Engl J Med 1989; 320:271–7.)