Factors associated with recruitment and screening in the Treatment for Adolescents with Depression Study (TADS)
Factors associated with recruitment and screening in the Treatment for Adolescents with Depression Study (TADS)
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DOI：
10.1097/chi.0b013e3180582019
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发表时间：
2007-07-01
影响因子：
13.3
通讯作者：
March, John S.
中科院分区：
文献类型：
--
作者：
May, Diane E.;Hallin, Mary J.;March, John S.
前言：目的：检验与资格和随机化相关的因素，并考虑招募方法的效率。方法：对12~17岁的青少年进行电话筛查(N=2,804)，然后进行面对面评估(N=1,088)，用于青少年抑郁症的治疗研究。单独的Logistic回归模型，控制地点，检查性别、年龄、种族或招募来源是否与资格、提供书面同意或随机化有关。效率是根据每个注册参与者完成的电话屏幕数量计算出来的。结果：年龄较大的青少年不太可能符合电话筛查的条件(优势比[OR]0.81)。无论种族，由专业人士推荐的符合条件的青少年当面表示同意的几率更高(OR 1.56)。非裔美国人提供同意的几率在统计学上较低(OR 0.67)，特别是在通过广告招募的情况下(OR 0.54)。女性更有可能被诊断为严重抑郁障碍(OR 1.69)。在随机化参与者和在随机化前退出研究的合格青少年之间没有发现显著差异。结论：这些发现强调了使用多种策略招募青少年参加临床试验和提高对文化差异的敏感性的重要性，特别是在接触抑郁的非裔美国人时。
Objective: To examine factors associated with eligibility and randomization and consider the efficiency of recruitment methods. Method: Adolescents, ages 12 to 17 years, were telephone screened (N = 2,804) followed by in-person evaluation (N = 1,088) for the Treatment for Adolescents With Depression Study. Separate logistic regression models, controlling for site, examined whether sex, age, race, or source of recruitment was associated with eligibility, providing written consent, or randomization. Efficiency was calculated from the number of completed telephone screens per each enrolled participant. Results: Older adolescents were less likely to be eligible at telephone screening (odds ratio [OR] 0.81). Regardless of race, eligible adolescents who were referred by a professional had higher odds of presenting in-person for consent (OR 1.56). African Americans had statistically lower odds of providing consent (OR 0.67), particularly if recruited by advertisement (OR 0.54). Females were more likely to be diagnosed with major depressive disorder (OR 1.69). No significant differences were found between randomized participants and eligible adolescents who withdrew from the study before randomization. Conclusions: These findings underscore the importance of using multiple strategies to recruit adolescents for clinical trial participation and enhancing sensitivity to cultural variations, especially when reaching out to depressed African Americans.