Neutrophil dysplasia caused by mycophenolate mofetil.
Neutrophil dysplasia caused by mycophenolate mofetil.
复制标题
吗替麦考酚酯引起的中性粒细胞发育不良。
DOI：
10.1097/00007890-200012150-00012
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发表时间：
2000
期刊：
影响因子：
6.2
通讯作者：
N. Banner
中科院分区：
文献类型：
--
作者：
Rajashi Banerjee;Ozay Halil;Barbara J. Bain;David Cummins;N. Banner
两名移植受者在接受霉酚酸酯治疗时，其循环中性粒细胞出现了明显的形态异常。这些变化包括核分叶减少和核染色质异常聚集，可能与鸟苷核苷合成的抑制有关。在这两种情况下，中性粒细胞异常先于中性粒细胞减少症的发展，因此是即将发生血液学毒性的征兆。停药后血液学变化消失。
Two transplant recipients developed striking morphological abnormalities in their circulating neutrophils while receiving mycophenolate. The changes included nuclear hypolobulation and abnormal clumping of nuclear chromatin and were presumably related to inhibition of guanosine nucleoside synthesis. In both cases the neutrophil abnormalities preceded the development of neutropenia and were thus a sign of impending hematological toxicity. The hematological changes resolved after the drug was discontinued.