Supplemental vitamin E intake and prostate cancer risk in a large cohort of men in the United States.
Supplemental vitamin E intake and prostate cancer risk in a large cohort of men in the United States.
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发表时间：
1999-10
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通讯作者：
J. Chan;M. Stampfer;Jing Ma;E. Rimm;W. Willett;E. Giovannucci
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作者：
J. Chan;M. Stampfer;Jing Ma;E. Rimm;W. Willett;E. Giovannucci
最近在芬兰进行的一项补充维生素E和β-胡萝卜素预防男性吸烟者肺癌的临床试验报告说，维生素E对前列腺癌的发病率和死亡率具有意想不到的强大保护作用。我们的目的是前瞻性地研究在不同的美国人群中补充维生素E的摄入量和前列腺癌的风险。1986年，我们确定了47，780名美国男性健康专业人员，他们没有被诊断出癌症，他们完成了饮食和生活方式问卷;补充维生素E和前列腺癌发病率每两年更新一次，直到1996年。我们用多变量逻辑回归模型估计相对危险度。在1986 - 1996年间，共诊断出1896例（非A1期）、522例前列腺外和232例转移性或致命性前列腺癌病例。与不补充维生素E的男性相比，每天补充至少100 IU维生素E的男性总体多变量RR为1.07（95%置信区间[CI]，0.95 - 1.20），转移性或致命性前列腺癌的多变量RR为1.14（95% CI，0.82 - 1.59）。目前使用特定维生素E补充剂或多种维生素E的使用，剂量和总持续时间与风险无关。然而，在目前吸烟者和最近戒烟者中，与非使用者相比，每天补充至少100 IU维生素E的人转移性或致命性前列腺癌的RR为0.44（95%CI，0.18 - 1.07）。因此，补充维生素E一般与前列腺癌风险无关，但补充维生素E与当前吸烟者和近期戒烟者转移性或致命性前列腺癌风险之间的提示性负相关与芬兰吸烟者试验一致，值得进一步研究。
A clinical trial of vitamin E and beta-carotene supplementation for lung cancer prevention among male smokers in Finland recently reported an unexpected, strong protective effect of vitamin E against prostate cancer incidence and mortality. Our objective was to prospectively examine supplemental vitamin E intake and prostate cancer risk in a distinct U.S. population. In 1986, we identified 47,780 U.S. male health professionals, free from diagnosed cancer, who completed a dietary and lifestyle questionnaire; supplemental vitamin E and prostate cancer incidence were updated biennially through 1996. We estimated relative risks (RRs) from multivariate pooled logistic regression models. There were 1896 total (non-stage A1), 522 extraprostatic, and 232 metastatic or fatal incident prostate cancer cases diagnosed between 1986-1996. Men consuming at least 100 IU of supplemental vitamin E daily had multivariate RRs of 1.07 (95% confidence interval [CI], 0.95-1.20) for total and 1.14 (95% CI, 0.82-1.59) for metastatic or fatal prostate cancer compared with those consuming none. Current use, dosage, and total duration of use of specific vitamin E supplements or multivitamins were not associated with risk. However, among current smokers and recent quitters, those who consumed at least 100 IU of supplemental vitamin E per day had a RR of 0.44 (95% CI, 0.18-1.07) for metastatic or fatal prostate cancer compared with nonusers. Thus, supplemental vitamin E was not associated with prostate cancer risk generally, but a suggestive inverse association between supplemental vitamin E and risk of metastatic or fatal prostate cancer among current smokers and recent quitters was consistent with the Finnish trial among smokers and warrants further investigation.