Rice protein improves adiposity, body weight and reduces lipids level in rats through modification of triglyceride metabolism.
Rice protein improves adiposity, body weight and reduces lipids level in rats through modification of triglyceride metabolism.
复制标题
大米蛋白通过改变甘油三酯代谢来改善大鼠的肥胖、体重并降低血脂水平
DOI：
10.1186/1476-511x-11-24
复制
发表时间：
2012-02-13
影响因子：
4.5
通讯作者：
Yang HK
中科院分区：
文献类型：
--
作者：
Yang L;Chen JH;Lv J;Wu Q;Xu T;Zhang H;Liu QH;Yang HK
为了阐明大米蛋白是否具有改善血脂水平和肥胖的重要功能，我们在喂食富含胆固醇的饮食2周的7周大雄性Wistar大鼠中研究了碱性提取的大米蛋白（RP-A）和α-淀粉酶（RP-E）对甘油三酯代谢的影响，并与酪蛋白（CAS）进行了比较。与CAS相比，RP喂养显着降低了血浆葡萄糖和脂质浓度（P < 0.05），并且肝脏脂质积累显着降低（P < 0.05）。与CAS相比，RP-A和RP-E显着降低肝脏脂肪酸合酶（FAS）、葡萄糖6-磷酸脱氢酶（G6PD）和苹果酸脱氢酶（MDH）活性（P < 0.05），而脂蛋白脂肪酶（PL）和肝脂肪酶（HL）活性显着增强（P < 0.05）。 RP-A 和 RP-E 之间的脂质水平和酶活性均无差异（P > 0.05）。蛋白质消化率与沉积脂肪呈显着正相关（r = 0.8567，P < 0.05），血浆TG浓度也呈显着正相关（r = 0.8627，P < 0.05）。目前的研究表明，大米蛋白可以改变甘油三酯的代谢，从而改善体重和肥胖。结果表明，大米蛋白的降甘油三酯作用以及抗肥胖潜力归因于脂肪分解的上调和脂肪生成的下调，而大米蛋白的较低消化率可能是其降脂作用的主要调节剂。
To elucidate whether rice protein can possess a vital function in improving lipids level and adiposity, the effects of rice proteins extracted by alkaline (RP-A) and α-amylase (RP-E) on triglyceride metabolism were investigated in 7-week-old male Wistar rats fed cholesterol-enriched diets for 2 weeks, as compared with casein (CAS). Compared with CAS, plasma concentrations of glucose and lipids were significantly reduced by RP-feeding (P < 0.05), as well as hepatic accumulation of lipids (P < 0.05). RP-A and RP-E significantly depressed the hepatic activities of fatty acid synthase (FAS), glucose 6-phosphate dehydrogenase (G6PD) and malate dehydrogenase (MDH) (P < 0.05), whereas the activities of lipoprotein lipase (PL) and hepatic lipase (HL) were significantly stimulated (P < 0.05), as compared to CAS. Neither lipids level nor activities of enzymes were different between RP-A and RP-E (P > 0.05). There was a significant positive correlation between protein digestibility and deposit fat (r = 0.8567, P < 0.05), as well as the plasma TG concentration (r = 0.8627, P < 0.05). The present study demonstrates that rice protein can modify triglyceride metabolism, leading to an improvement of body weight and adiposity. Results suggest that the triglyceride-lowering action as well as the potential of anti-adiposity induced by rice protein is attributed to upregulation of lipolysis and downregulation of lipogenesis, and the lower digestibility of rice protein may be the main modulator responsible for the lipid-lowering action.