The Glioma Stem Cell Model in the Era of Single-Cell Genomics
The Glioma Stem Cell Model in the Era of Single-Cell Genomics
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DOI：
10.1016/j.ccell.2020.04.001
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发表时间：
2020-05-11
期刊：
影响因子：
50.3
通讯作者：
Tirosh, Itay
中科院分区：
文献类型：
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作者：
Suva, Mario L.;Tirosh, Itay
胶质瘤干细胞（GSC）被认为是胶质瘤发生、演变和对现有疗法耐药性的基础。虽然GSC的功能证据是丰富的，肿瘤异质性和GSC测定的内在局限性代表了该领域的障碍。从这个角度来看，我们重新审视GSC模型，根据最近的单细胞表达谱研究。我们强调了胶质瘤的类别如何在其细胞结构上有所不同，并将观察到的细胞状态与已建立的GSC标记物联系起来。此外，我们提出了一套单细胞知情的定义作为我们的神经胶质瘤的细胞结构和潜在的治疗前景的理解框架。
Glioma stem cells (GSCs) are thought to underlie glioma initiation, evolution, and resistance to existing therapies. Although functional evidence for GSCs is abundant, tumor heterogeneity and intrinsic limitations in GSC assays have represented barriers for the field. In this perspective, we revisit the GSC model in light of recent single-cell expression profiling studies. We highlight how classes of glioma differ in their cellular architecture and relate the observed cellular states to established GSC markers. We additionally propose a set of single-cell informed definitions as a framework for our understanding of the cellular architecture of gliomas and a potential therapeutic outlook.