Expression of epidermal growth factor-receptor related protein (ERRP) in human colorectal carcinogenesis.

Expression of epidermal growth factor-receptor related protein (ERRP) in human colorectal carcinogenesis.
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表皮生长因子受体相关蛋白(ERRP)在人结直肠癌发生中的表达。

DOI:
10.1016/j.canlet.2004.04.034
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发表时间:
2004
期刊:
影响因子:
9.7
通讯作者:
Majumdar,AdhipPN
Majumdar,AdhipPN
中科院分区:
医学1区
文献类型:
--
作者:
Jaszewski,Richard;Levi,Edi;Sochacki,Paula;Frank,John;Kucuk,Omer;Axelrod,BradleyN;Majumdar,AdhipPN

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We hypothesize that ERRP (EGFR-related protein), a recently identified negative regulator of EGFR may modulate EGFR function in colorectal carcinogenesis. The expression of ERRP and EGFR in normal and neoplastic colorectal tissue was examined. ERRP was highly expressed in normal colonic mucosa and benign colorectal adenomas, but lower in colorectal cancer. Mean scores for ERRP expression decreased significantly across well differentiated, moderately well differentiated and poorly differentiated (P=0.002) tumors, respectively. ERRP expression became more attenuated in polyps with increasing grades of dysplasia. In contrast, expression of EGFR was inversely related to ERRP in representative samples of normal and neoplastic tissues.
DOI: 10.1093/oxfordjournals.bmb.a072464
发表时间: 1991-01-01
影响因子: 6.7
作者:
GULLICK, WJ
通讯作者: GULLICK, WJ
DOI: --
发表时间: 1998
期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子: --
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DOI: --
发表时间: 1991
影响因子: 8.8
作者:
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DOI: --
发表时间: 1983
期刊:
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