A neural basis for the perception of voices in external auditory space
A neural basis for the perception of voices in external auditory space
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DOI：
10.1093/brain/awg015
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发表时间：
2003-01-01
期刊：
影响因子：
14.5
通讯作者：
Woodruff, PWR
中科院分区：
文献类型：
--
作者：
Hunter, MD;Griffiths, TD;Woodruff, PWR
我们使用正常受试者的功能成像来识别外听空间中声音感知的神经基质。这一基本过程在精神病中可能是不正常的，当不是真实的外部听觉对象的声音（听觉言语幻觉）可能看起来来自外部空间。声音作为外部空间的物体的感知依赖于外耳的过滤。扭曲这一过程的精神病与大脑皮层有关。对12名正常受试者进行了功能性磁共振成像，使用扫描仪内部模拟“内部头部”和“外部头部”的声音，以典型的听觉语言幻觉的形式。通过对比这两种情况下的大脑活动，我们可以验证这样一个假设，即外部空间（“外部头部”）的声音感知是由颞平面回（PT）后的联合听觉皮层和顶叶下小叶组成的温度顶叶网络。对“外部头部”和“内部头部”声音的反应的群体分析显示，左侧PT仅显着激活。这在三个实验中得到了证明，其中主要的侧化刺激是向右，向左或平衡。这些发现表明，在外部空间的声音感知中，左PT的关键参与并不依赖于精确的空间位置。在此基础上，我们提出了一个模型的错误感知的外部定位听觉语言幻觉。
We used functional imaging of normal subjects to identify the neural substrate for the perception of voices in external auditory space. This fundamental process can be abnormal in psychosis, when voices that are not true external auditory objects (auditory verbal hallucinations) may appear to originate in external space. The perception of voices as objects in external space depends on filtering by the outer ear. Psychoses that distort this process involve the cerebral cortex. Functional magnetic resonance imaging was carried out on 12 normal subjects using an inside-the-scanner simulation of 'inside head' and 'outside head' voices in the form of typical auditory verbal hallucinations. Comparison between the brain activity associated with the two conditions allowed us to test the hypothesis that the perception of voices in external space ('outside head') is subserved by a temperoparietal network comprising association auditory cortex posterior to Heschl's gyrus [planum temporale (PT)] and inferior parietal lobule. Group analyses of response to 'outside head' versus 'inside head' voices showed significant activation solely in the left PT. This was demonstrated in three experiments in which the predominant lateralization of the stimulus was to the right, to the left or balanced. These findings suggest a critical involvement of the left PT in the perception of voices in external space that is not dependent on precise spatial location. Based on this, we suggest a model for the false perception of externally located auditory verbal hallucinations.