Targeting cancer cells: magnetic nanoparticles as drug carriers
Targeting cancer cells: magnetic nanoparticles as drug carriers
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DOI：
10.1007/s00249-006-0042-1
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发表时间：
2006-05-01
影响因子：
2
通讯作者：
Parak, Fritz G.
中科院分区：
文献类型：
--
作者：
Alexiou, Christoph;Schmid, Roswitha J.;Parak, Fritz G.
利用纳米粒子作为载体的磁性药物靶向是一种很有前途的癌症治疗方法，避免了传统化疗的副作用。我们使用氧化铁纳米颗粒覆盖的淀粉衍生物与磷酸基团结合米托蒽醌作为化疗药物。在这封信中，我们表明，在肿瘤位置的强磁场梯度积累的纳米粒子。电子显微镜观察表明，肿瘤组织和肿瘤细胞中可富集铁氟化合物。
Magnetic drug targeting employing nanoparticles as carriers is a promising cancer treatment avoiding side effects of conventional chemotherapy. We used iron oxide nanoparticles covered by starch derivatives with phosphate groups which bound mitoxantrone as chemotherapeutikum. In this letter we show that a strong magnetic field gradient at the tumour location accumulates the nanoparticles. Electron microscope investigations show that the ferroflulds can be enriched in tumour tissue and tumour cells.