Determinants of Antiviral Effectiveness in Influenza Virus A Subtype H5N1
Determinants of Antiviral Effectiveness in Influenza Virus A Subtype H5N1
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DOI：
10.1093/infdis/jis509
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发表时间：
2012-11-01
影响因子：
6.4
通讯作者：
Dreyer, Nancy A.
中科院分区：
文献类型：
--
作者：
Chan, Paul K. S.;Lee, Nelson;Dreyer, Nancy A.
背景奥司他韦被广泛用于治疗流感病毒A亚型H5N1（以下称为“H5N1”）感染，但与任何干预一样，奥司他韦并不总是有效的。我们使用来自10个国家的禽流感登记数据，根据病毒分支、年龄、呼吸衰竭和皮质类固醇或类固醇的连续治疗，检查了215例确诊H5N1感染并接受奥司他韦治疗的患者的死亡风险。感染者的中位年龄为18岁，50%为男性。最高的死亡率发生在2.1型病毒流行的国家，最低的发生在2.2型病毒流行的国家（P <0.001）。在单变量分析中，
Background. Oseltamivir is widely used as treatment for influenza virus A subtype H5N1 (hereafter, "H5N1") infection but, like any intervention, is not always effective.Methods. We used Avian Influenza Registry data from 10 countries to examine the risk of death in 215 patients with confirmed H5N1 infection who were treated with oseltamivir, according to viral clade, age, respiratory failure, and adjunctive treatment with corticosteroids or antibiotics.Results. The median age of infected individuals was 18 years, and 50% were male. The highest fatality rate occurred in a country with clade 2.1 virus circulation, and the lowest occurred in countries with clade 2.2 virus circulation (P < .001). In univariate analyses, age of