Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy
Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy
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DOI：
10.1093/annonc/mdh348
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发表时间：
2004-09-01
影响因子：
50.5
通讯作者：
Zanna, C
中科院分区：
文献类型：
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作者：
Cavaletti, G;Bogliun, G;Zanna, C
背景：我们研究了化疗引起的周围神经毒性（CIPN）的临床症状或神经生长因子（NGF）循环水平来预测 CIPN 最终结果的可能性。患者和方法：62 名患有局部晚期鳞状宫颈癌的女性接受 TP（紫杉醇 175 mg/m(2) 输注 3 小时加顺铂 75 mg/m(2)）或 TIP（TP 加异环磷酰胺 5）治疗mg/m（2））在化疗前和化疗期间根据总神经病变评分（TNS）进行检查和评分。结果：通过振动知觉和深腱反射评估观察到与 CIPN 最终严重程度的相关性，而针敏感性、强度和自主神经症状和体征没有提供信息。 NGF循环水平的降低与CIPN的严重程度之间存在高度显着的相关性（r=-0.579；P
Background: We investigated the possible use of clinical signs of chemotherapy-induced peripheral neurotoxicity (CIPN) or of nerve growth factor (NGF) circulating levels to predict the final outcome of CIPN.Patients and methods: Sixty-two women affected by locally advanced squamous cervical carcinoma treated with TP (paclitaxel 175 mg/m(2) over a 3 h infusion plus cisplatin 75 mg/m(2)) or TIP (TP plus ifosphamide 5 mg/m(2)) were examined and scored according to the Total Neuropathy Score (TNS), before and during chemotherapy.Results: A correlation with the final severity of CIPN was observed with vibration perception and deep tendon reflex evaluation, while pin sensibility, strength, and autonomic symptoms and signs were not informative. A highly significant correlation existed between the decrease in circulating levels of NGF and the severity of CIPN (r=-0.579; P