Utility of azathioprine metabolite measurements in post‐transplant recurrent autoimmune and immune‐mediated hepatitis
Utility of azathioprine metabolite measurements in post‐transplant recurrent autoimmune and immune‐mediated hepatitis
复制标题
硫唑嘌呤代谢物测量在移植后复发性自身免疫性和免疫介导性肝炎中的应用
DOI：
10.1111/j.1399-3046.2004.00273.x
复制
发表时间：
2004
影响因子：
1.3
通讯作者：
M. Malágo
中科院分区：
文献类型：
--
作者：
E. Molmenti;M. Malágo
儿科移植的成功是由多种因素决定的，既有科学的，也有社会的。儿科一词涵盖了广泛的年龄段，为卫生保健专业人员提供了从产后到成年早期的各种患者。这一患者群体具有内在的增长和发育阶段。因此，结果既受到病理生理实体的影响，也受到与不同生命阶段相关的心理社会事件的影响。在这种心态下，我们怀着极大的兴趣和喜悦阅读了伦博、施奈德和埃姆雷博士关于硫唑嘌呤代谢物测量在移植后复发的自身免疫性和免疫介导性肝炎中的应用的手稿(1)。在报告中，他们概述了一种病因尚不清楚的疾病，发生在不同的年龄段。它的治疗方法是通过一种在移植中很少使用的药物。这种药品被发现在剂量上有不同的变化。更耐人寻味的是，结果不仅取决于治疗的充分性，还取决于患者及其照顾者的依从性。作者在他们的手稿中概述了三个非常相关的临床概念：
Success in pediatric transplantation is guided by multiple factors, both scientific and social in nature. The wide range of age groups encompassed under the term pediatric provides health care professionals with a variety of patients ranging from post-partum to early adulthood. This patient population has inherent growth and developmental stages. As such, outcomes are affected by both pathophysiological entities as well as by psychosocial events associated with the various life stages. With this mindset, we read with great interest and pleasure Drs Rumbo, Shneider, and Emre’s manuscript on Utility of azathioprine metabolite measurements in post-transplant recurrent autoimmune and immune-mediated hepatitis (1). In it, they outline a disease with a still unclear etiology that occurs at various age groups. Its treatment is by means of an otherwise seldom-used agent in transplantation. This pharmaceutical product is found to have ageassociated variations in dosing. To make the plot even more intriguing, the outcome not only depends on the adequacy of treatment but also on the compliance of patients and their caregivers. The authors outline in their manuscript three very relevant clinical concepts: