Palladium-catalyzed C-H homocoupling of furans and thiophenes using oxygen as the oxidant.
Palladium-catalyzed C-H homocoupling of furans and thiophenes using oxygen as the oxidant.
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DOI：
10.1021/ol501019y
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发表时间：
2014-05
期刊：
影响因子：
5.2
通讯作者：
Na Li;Yan-Lei Zhang;Shuai Mao;Ya-Ru Gao;Dong‐Dong Guo;Yong-Qiang Wang
中科院分区：
文献类型：
--
作者：
Na Li;Yan-Lei Zhang;Shuai Mao;Ya-Ru Gao;Dong‐Dong Guo;Yong-Qiang Wang
开发了一种通用且有效的钯催化的呋喃和噻吩分子间直接 C-H 自偶联反应。该反应的特点是使用分子氧作为唯一氧化剂并具有完全的C5位区域选择性。 C2-和C3-取代的呋喃或噻吩都是合适的底物。该方法提供了一种在温和反应条件下直接、简便且经济地制备联呋喃和联噻吩的路线。
A general and efficient palladium-catalyzed intermolecular direct C-H homocoupling of furans and thiophenes has been developed. The reaction is characterized by using molecular oxygen as the sole oxidant and complete C5-position regioselectivity. Both C2- and C3-substituted furans or thiophenes are appropriate substrates. The approach provides a straightforward, facile, and economical route to bifurans and bithiophenes under mild reaction conditions.