Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study
Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study
复制标题
DOI：
10.1503/jpn.110187
复制
发表时间：
2013-01-01
影响因子：
4.3
通讯作者：
Noll-Hussong, Michael
中科院分区：
文献类型：
--
作者：
Otti, Alexander;Guendel, Harald;Noll-Hussong, Michael
背景：在没有刺激的情况下，人类大脑会自发地在内在连接网络（ICNs）中产生高度组织化的低频神经活动波动。此外，如果没有足够的解释性伤害性输入，躯体形式疼痛障碍患者会出现疼痛症状，从而暗示中枢疼痛稳态失调。本研究旨在测试在静息状态下，与疼痛相关的icn，如默认模式网络（DMN）、束岛网络（CIN）和感觉运动网络（SMN）之间的相互作用是否在躯体形式疼痛中发生改变。方法：对躯体型疼痛障碍患者和健康对照者进行静息功能磁共振成像，时间为370秒。采用数据驱动的方法，对icn进行隔离，并计算功能网络连通性（FNC）。结果：21例患者和19例对照组纳入研究。CIN与SMN/前DMN、前DMN与后DMN/SMN、后DMN与SMN之间存在显著的FNC （p < 0.05，校正错误发现率）。有趣的是，FNC没有发现组间差异。局限性：本研究最重要的局限性是相对较短的静息状态范式。结论：据我们所知，我们的结果首次证明了疼痛相关icn的静息FNC。然而，我们的研究结果表明，FNC信号本身并不能表征支撑躯体形式疼痛障碍的假定中枢功能障碍。
Background: Without stimulation, the human brain spontaneously produces highly organized, low-frequency fluctuations of neural activity in intrinsic connectivity networks (ICNs). Furthermore, without adequate explanatory nociceptive input, patients with somatoform pain disorder experience pain symptoms, thus implicating a central dysregulation of pain homeostasis. The present study aimed to test whether interactions among pain-related ICNs, such as the default mode network (DMN), cingular-insular network (CIN) and sensorimotor network (SMN), are altered in somatoform pain during resting conditions. Methods: Patients with somatoform pain disorder and healthy controls underwent resting functional magnetic resonance imaging that lasted 370 seconds. Using a data-driven approach, the ICNs were isolated, and the functional network connectivity (FNC) was computed. Results: Twenty-one patients and 19 controls enrolled in the study. Significant FNC (p < 0.05, corrected for false discovery rate) was detected between the CIN and SMN/anterior DMN, the anterior DMN and posterior DMN/SMN, and the posterior DMN and SMN. Interestingly, no group differences in FNC were detected. Limitations: The most important limitation of this study was the relatively short resting state paradigm. Conclusion: To our knowledge, our results demonstrated for the first time the resting FNC among pain-related ICNs. However, our results suggest that FNC signatures alone are not able to characterize the putative central dysfunction underpinning somatoform pain disorder.