Dietary patterns and the risk of colorectal adenomas: the Black Women's Health Study.
Dietary patterns and the risk of colorectal adenomas: the Black Women's Health Study.
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DOI：
10.1158/1055-9965.epi-10-1213
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Adams-Campbell LL
中科院分区：
文献类型：
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作者：
Makambi KH;Agurs-Collins T;Bright-Gbebry M;Rosenberg L;Palmer JR;Adams-Campbell LL
结直肠腺瘤是良性病变，可能是结直肠癌的前兆。没有针对非裔美国妇女的研究调查了饮食模式和结直肠腺瘤的风险。我们检查了黑人妇女健康研究（BWHS）的数据，以确定饮食模式是否与结直肠腺瘤的风险相关。这是一项前瞻性队列研究，共有59000名参与者，自1995年以来每两年随访一次。从1997年到2007年，在155,414人年的随访中，至少进行过一次结肠镜检查的妇女中，发现了620例结直肠腺瘤。使用Cox回归模型，我们获得了两种饮食模式中结直肠腺瘤的发生率比（IRR），并对其他结直肠腺瘤危险因素进行了调整。两种饮食模式，西方和谨慎，被用来评估饮食摄入量和腺瘤风险之间的关系。谨慎饮食的最高五分位数与最低五分位数相比，总体降低34%的结直肠腺瘤风险显著相关（发病率比，IRR=0.66; 95% CI, 0.50-0.88； p为趋势，< 0.01）。西部模式得分越高，结直肠腺瘤的风险越高（IRR = 1.42，最高五分位数相对于最低五分位数的95% CI 1.09-1.85； p趋势为0.01）。我们的研究结果表明，非裔美国妇女可以通过遵循谨慎的饮食模式和避免更多的西方模式来降低患结直肠腺瘤的风险。饮食调整可能对非裔美国妇女预防结直肠腺瘤有很大影响。
Colorectal adenomas are benign lesions that may be precursors to colorectal cancer. No studies of African American women have investigated dietary patterns and the risk of colorectal adenomas. We examined data from the Black Women's Health Study (BWHS) to determine whether dietary patterns are associated with the risk of colorectal adenomas. This is a prospective cohort study of 59,000 participants followed biennially since 1995. During 155,414 person-years of follow-up from 1997 to 2007 among women who had had at least one screening colonoscopy, 620 incident cases of colorectal adenomas were identified. Using Cox regression models, we obtained incident rate ratios (IRR) for colorectal adenoma in relation to quintiles of each of two dietary patterns, adjusting for other colorectal adenoma risk factors. Two dietary patterns, Western and prudent, were utilized to assess the association between dietary intake and adenoma risk. The highest quintile of prudent diet, relative to the lowest quintile, was significantly associated with 34% lower colorectal adenoma risk overall (incidence rate ratio, IRR=0.66; 95% CI, 0.50-0.88; p for trend, < 0.01). Higher scores on the Western pattern were associated with higher risk of colorectal adenoma (IRR = 1.42, 95% CI 1.09-1.85 for the highest quintile relative to the lowest; p trend, 0.01). Our findings suggest that African American women may be able to reduce their risk of developing colorectal adenomas by following a prudent dietary pattern and avoiding a more Western pattern. A dietary modification could have a strong impact in colorectal adenoma prevention in African American women.