Glioma stem cells and their roles within the hypoxic tumor microenvironment.
Glioma stem cells and their roles within the hypoxic tumor microenvironment.
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胶质瘤干细胞及其在缺氧肿瘤微环境中的作用。
DOI：
10.7150/thno.41692
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发表时间：
2021
期刊：
影响因子：
12.4
通讯作者：
Hjelmeland AB
中科院分区：
文献类型：
--
作者：
Boyd NH;Tran AN;Bernstock JD;Etminan T;Jones AB;Gillespie GY;Friedman GK;Hjelmeland AB
肿瘤微环境是癌症中细胞改变的结果，其支持不受限制的生长和增殖，并导致细胞行为的进一步改变，这对肿瘤进展至关重要。已知血管生成和治疗抗性受缺氧和其他肿瘤微环境（如酸性应激）调节，这两者都是胶质母细胞瘤微环境的核心特征。缺氧也被证明可以促进非肿瘤细胞和肿瘤细胞中的干细胞样状态。在神经胶质瘤中，神经胶质瘤干细胞（GSC）在肿瘤生长、血管生成和治疗抗性中起着重要作用，进一步研究肿瘤微环境和GSC之间的相互作用对于寻找胶质母细胞瘤的更好治疗方案至关重要。因此，我们总结了缺氧和酸应激对GSC信号转导和生物表型的影响，以及抑制这些途径的潜在方法。
Tumor microenvironments are the result of cellular alterations in cancer that support unrestricted growth and proliferation and result in further modifications in cell behavior, which are critical for tumor progression. Angiogenesis and therapeutic resistance are known to be modulated by hypoxia and other tumor microenvironments, such as acidic stress, both of which are core features of the glioblastoma microenvironment. Hypoxia has also been shown to promote a stem-like state in both non-neoplastic and tumor cells. In glial tumors, glioma stem cells (GSCs) are central in tumor growth, angiogenesis, and therapeutic resistance, and further investigation of the interplay between tumor microenvironments and GSCs is critical to the search for better treatment options for glioblastoma. Accordingly, we summarize the impact of hypoxia and acidic stress on GSC signaling and biologic phenotypes, and potential methods to inhibit these pathways.
影响因子：
5.6
作者：
Ma H;Zhang Y;Wang H;Han C;Lei R;Zhang L;Yang Z;Rao L;Qing H;Xiang J;Deng Y
通讯作者：
Deng Y
影响因子：
5.6
作者：
Gu Y;Chang TT;Wang J;Jaiswal JK;Edwards D;Downes NJ;Liyanage HDS;Lynch CRH;Pruijn FB;Hickey AJR;Hay MP;Wilson WR;Hicks KO
通讯作者：
Hicks KO