Membrane-containing viruses with icosahedrally symmetric capsids
Membrane-containing viruses with icosahedrally symmetric capsids
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DOI：
10.1016/j.sbi.2007.03.005
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发表时间：
2007-04-01
影响因子：
6.8
通讯作者：
Butcher, Sarah J.
中科院分区：
文献类型：
--
作者：
Huiskonen, Juha T.;Butcher, Sarah J.
具有二十面体对称蛋白衣壳和膜的病毒感染宿主的所有三个生命域。类似的结构原理被不同的病毒家族所共享，例如双链DNA病毒，如PRD1和STIV。在病毒组装过程中，膜脂是选择性地从宿主细胞中获得的。噬菌体PRD1的x射线结构显示，脂质在两个小叶之间不对称分布，小面长度由一个卷尺蛋白控制。在大多数含膜病毒中，病毒和宿主膜在病毒进入时融合。在甲病毒、黄病毒和疱疹病毒的已知系统中，融合是由病毒糖蛋白介导的。最近的结构进展揭示了如何使用非常不同的蛋白质结构来形成延伸到靶细胞膜的三聚体延伸，然后折叠回来介导靶细胞膜和病毒膜的融合。
Viruses with an icosahedrally symmetric protein capsid and a membrane infect hosts from all three domains of life. Similar architectural principles are shared by different viral families, as exemplified by double-stranded DNA viruses such as PRD1 and STIV. During virus assembly, the membrane lipids are selectively acquired from the host cell. The X-ray structure of bacteriophage PRD1 revealed that the lipids are asymmetrically distributed between the two leaflets and facet length is controlled by a tape-measure protein. In most membrane-containing viruses, viral and host membranes fuse during viral entry. In the best-understood systems of the alphaviruses, flaviviruses and herpes viruses, fusion is mediated by viral glycoproteins. Recent structural advances reveal how very different protein architectures can be used to form trimeric extensions that extend into the target cell membrane and then fold back to mediate fusion of the target and viral membranes.