Social communication and emotion difficulties and second to fourth digit ratio in a large community-based sample
Social communication and emotion difficulties and second to fourth digit ratio in a large community-based sample
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DOI：
10.1186/s13229-015-0063-7
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发表时间：
2015-12-28
期刊：
影响因子：
6.2
通讯作者：
Micali, Nadia
中科院分区：
文献类型：
--
作者：
Barona, Manuela;Kothari, Radha;Micali, Nadia
背景资料：最近的研究调查自闭症谱系障碍（ASD）的极端男性大脑理论引起了人们的注意，自闭症类型的社会困难可能与产前高睾酮暴露有关。本研究的目的是调查社会沟通和情绪识别困难和第二至第四位数字比例（2D：4D）和循环母亲睾酮在怀孕期间在一个大型的社区为基础的队列：雅芳纵向研究的父母和孩子（ALSPAC）之间的关联。第二个目的是调查可能的性别差异的association.Methods：数据的社会沟通（社会和沟通障碍量表，N = 7165），情绪识别（情绪三角形，N = 5844和诊断分析的非语言的准确性，N = 7488）和2D：4D（第二至第四位数字的比例，N = 7159）收集在儿童和青少年早期的问卷调查和面对面的评估。共有3515名儿童获得了完整的数据。结果：男性2D：4D比值低于女性[t（3513）=-9.775，p = 0.001]。社交沟通和情感识别的测量结果与2D：4D比率的最低10%之间存在关联。母亲外周血睾酮水平与左手2D：4D显著相关[OR = 1.65，95% CI 1.1-2.4，p < 0.01]。结论：2D：4D与社交障碍之间的关系尚不明确。一种新的关联之间的极端措施的2D：4D的男性表明阈值效应，并保证复制。
Background: Recent research investigating the extreme male brain theory of autism spectrum disorders (ASD) has drawn attention to the possibility that autistic type social difficulties may be associated with high prenatal testosterone exposure. This study aims to investigate the association between social communication and emotion recognition difficulties and second to fourth digit ratio (2D:4D) and circulating maternal testosterone during pregnancy in a large community-based cohort: the Avon Longitudinal Study of Parents and Children (ALSPAC). A secondary aim is to investigate possible gender differences in the associations.Methods: Data on social communication (Social and Communication Disorders Checklist, N = 7165), emotion recognition (emotional triangles, N = 5844 and diagnostics analysis of non-verbal accuracy, N = 7488) and 2D:4D (second to fourth digit ratio, N = 7159) were collected in childhood and early adolescence from questionnaires and face-to-face assessments. Complete data was available on 3515 children. Maternal circulating testosterone during pregnancy was available in a subsample of 89 children.Results: Males had lower 2D:4D ratios than females [t (3513) = -9.775, p < 0.001]. An association was found between measures of social communication and emotion recognition, and the lowest 10 % of 2D:4D ratios. A significant association was found between maternal circulating testosterone and left hand 2D:4D [OR = 1.65, 95 % CI 1.1-2.4, p < 0.01].Conclusions: Previous findings on the association between 2D:4D and social communication difficulties were not confirmed. A novel association between an extreme measure of 2D:4D in males suggests threshold effects and warrants replication.