Characterization of tin-technetium colloid in technetium-labeled albumin preparations.
Characterization of tin-technetium colloid in technetium-labeled albumin preparations.
复制标题
锝标记白蛋白制剂中锡-锝胶体的表征。
DOI：
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发表时间：
1978
影响因子：
9.3
通讯作者：
L. Blanton
中科院分区：
文献类型：
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作者：
W. A. Petit;F. Deland;G. Pepper;L. Blanton
以凝胶过滤为测定方法，对人血清白蛋白(HSA)体系进行了重新研究。除~(99m)Tc-HSA外，还分离出了两种放射性组分。这两种组分都是不同颗粒大小的锡-锶胶体，并且每种组分的相对含量都与pH有关。蛋白质诱导X射线发射分析(PIXE)和大鼠体内组织分布进一步表征了该胶体。通过这种凝胶过滤方法，对商用的~(99)m人血清白蛋白试剂盒进行了评估，发现存在不同数量的胶体。
The Tc-99m human serum albumin (HSA) system has been reinvestigated with gel filtration as the assay method. Other than Tc-99m HSA, two radioactive components have been isolated by this technique. Both components are tin-technetium colloids of differing particle sizes, and the relative quantity of each one is pH-dependent. The colloid has been further characterized by protein-induced x-ray emission analysis (PIXE) and by tissue distribution in rats. By this gel-filtration method, commercial Tc-99m HSA kits have been evaluated and have revealed varying amounts of colloids present.