Magnetoencephalography shows atypical sensitivity to linguistic sound sequences in autism spectrum disorder.
Magnetoencephalography shows atypical sensitivity to linguistic sound sequences in autism spectrum disorder.
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DOI：
10.1097/wnr.0000000000000643
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发表时间：
2016-09-07
期刊：
影响因子：
1.7
通讯作者：
Lajiness-O'Neill R
中科院分区：
文献类型：
--
作者：
Brennan JR;Wagley N;Kovelman I;Bowyer SM;Richard AE;Lajiness-O'Neill R
神经科学证据指出自闭症谱系障碍（ASD）患者的非典型听觉处理，但其对接受性语言的影响仍不清楚。使用脑磁图（MEG）和被动听力任务，我们测试语音声音处理的级联效应。ASD儿童和年龄匹配的对照参与者（8-12岁）听随机的语言刺激，要么符合或不符合英语中控制辅音序列的语音规则（例如，法律的“vip”与非法的“vip”）。使用波束形成器源分析来分离左右听觉皮层中对这些刺激的诱发响应（0.1 - 30 Hz）。ASD参与者的右听觉反应，但不是控制参与者，表现出衰减的反应，非法序列相对于法律的序列，出现在发病后330毫秒左右的关键音素。这些结果表明，语音处理的影响，在ASD，可能是由于级联效应从中断的初始声学处理。
Neuroscientific evidence points towards atypical auditory processing in individuals with Autism Spectrum Disorders (ASD), yet the consequences of this for receptive language remain unclear. Using magnetoencephalography (MEG) and a passive listening task, we test for cascading effects on speech sound processing. Children with ASD and age-matched control participants (8-12 y.o.) listened to nonce linguistic stimuli that either did or did not conform to the phonological rules that govern consonant sequences in English (e.g. legal “vimp” vs. illegal “vimk”). Beamformer source analysis was used to isolate evoked responses (0.1 – 30 Hz) to these stimuli in left and right auditory cortex. Right auditory responses from participants with ASD, but not control participants, showed an attenuated response to illegal sequences relative to legal sequences that emerged around 330 ms after the onset of the critical phoneme. These results suggest that phonological processing is impacted in ASD, perhaps due to cascading effects from disrupted initial acoustic processing.