Tickling induces reward in adolescent rats
Tickling induces reward in adolescent rats
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DOI：
10.1016/s0031-9384(00)00411-x
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发表时间：
2001-01-01
影响因子：
2.9
通讯作者：
Panksepp, J
中科院分区：
文献类型：
--
作者：
Burgdorf, J;Panksepp, J
在青春期的大鼠中，50千赫的声音在挠痒和打闹时最明显。下面的实验通过确定(1)挠痒是否是一个奖励事件，(2)社会或孤立的住房条件是否对反应有不同的影响（因为住房条件已被发现影响社会遭遇的奖励大小），以及(3)作用于mu -鸦片受体的药物是否调节挠痒，这被假设为控制积极的社会影响。通过提高操作行为、条件性位置偏好和接近措施，证明了挠痒是正向强化的。发声率与接近潜伏期之间存在显著负相关。与隔离住房相比，社会住房减少了瘙痒引起的叫声和接近速度。纳洛酮（1 mg/kg）增加了群居大鼠的发声能力，降低了孤立大鼠的发声能力（Ss）。这些发现表明，在啮齿类动物中，挠痒可以用来诱导积极的社会影响，并且它是由内源性阿片样物质调节的。(C) 2001爱思唯尔科学公司版权所有。
In adolescent rats, 50-kHz vocalizations are most evident during tickling and rough-and-tumble play. The following experiments evaluated whether 50-kHz vocalizations reflect positive social affect by determining (1) if tickling is a rewarding event, (2) if social or isolate housing conditions differentially influence the response (since housing condition has been found to effect the reward magnitude of social encounters), and (3) if drugs that work on mu -opiate receptors, which has been hypothesized to control positive social affect, modulate tickling. Tickling was positively reinforcing as demonstrated by elevated operant behavior, conditioned place preference, and approach measures. A significant negative correlation between vocalization rate and approach latency measures was found. Social housing reduced tickle-induced vocalizations and approach speeds compared to isolate housing. Naloxone (1 mg/kg) increased vocalization in the socially housed rats and decreased it in isolated Subjects (Ss). These findings suggest that tickling can be used to induce positive social affect in rodents, and that it is modulated by endogenous opioids. (C) 2001 Elsevier Science Inc. All rights reserved.