Post-training estrogen enhances spatial and object memory consolidation in female mice
Post-training estrogen enhances spatial and object memory consolidation in female mice
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DOI：
10.1016/j.pbb.2006.04.013
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发表时间：
2006-05-01
影响因子：
3.6
通讯作者：
Frick, Karyn M.
中科院分区：
文献类型：
--
作者：
Gresack, Jodi E.;Frick, Karyn M.
本研究旨在确定训练后注射水溶性形式的 17 β-雌二醇是否可以增强年轻雌性小鼠的空间和物体记忆巩固。切除卵巢的年轻雌性小鼠接受莫里斯水迷宫和物体识别任务的训练，注射0.1、0.2或0.4 mg/kg环糊精封装的17β-雌二醇或环糊精结合的载体，然后在延迟后重新测试。在水迷宫中，小鼠接受连续八次试验、注射，并在 24 小时后重新测试平台位置的记忆。所有小鼠都在第一天学会了寻找平台，但只有接受 0.2 mg/kg 雌二醇的小鼠在第二天记住了平台位置。在物体识别任务中，首先向小鼠展示两个相同的物体，注射后，然后在延迟 24 或 48 小时后向小鼠展示一个熟悉的新物体。对于这两种延迟，0.2 和 0.4 毫克/千克剂量都增强了对熟悉物体的记忆。这些数据表明，0.2 mg/kg剂量的雌二醇可以增强雌性小鼠多种类型的记忆巩固，并且表明空间记忆的有效剂量范围比物体记忆的有效剂量范围更窄。 (c) 2006 Elsevier Inc. 保留所有权利。
The present study was designed to determine if post-training injections of a water-soluble form of 17 beta-estradiol could enhance spatial and object memory consolidation in young female mice. Young ovariectomized female mice were trained in Morris water maze and object recognition tasks, injected with 0.1, 0.2, or 0.4 mg/kg cyclodextrin-encapsulated 17 beta-estradiol or cyclodextrin-conjugated vehicle, and then re-tested after a delay. In the water maze, mice were trained in eight consecutive trials, injected, and memory for the platform location was re-tested after 24 h. All mice learned to find the platform on Day 1, but only mice receiving 0.2 mg/kg estradiol remembered the platform location on Day 2. In the object recognition task, mice were first presented with two identical objects, injected, and then presented with a familiar and novel object after a 24- or 48-h delay. For both delays, the 0.2 and 0.4 mg/kg doses enhanced memory for the familiar object. These data demonstrate that a 0.2 mg/kg dose of estradiol can enhance multiple types of memory consolidation in female mice, and suggest a narrower effective dose range for spatial memory than for object memory. (c) 2006 Elsevier Inc. All rights reserved.