The organization of tight junctions in epithelia: Implications for mammary gland biology and breast tumorigenesis
The organization of tight junctions in epithelia: Implications for mammary gland biology and breast tumorigenesis
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DOI：
10.1023/b:jomg.0000017431.45314.07
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发表时间：
2003-10-01
影响因子：
2.5
通讯作者：
Bissell, MJ
中科院分区：
文献类型：
--
作者：
Itoh, M;Bissell, MJ
紧密连接（Tight junction, TJs）是细胞-细胞连接复合物的最顶端成分，在组织内细胞极性的建立和维持中起着至关重要的作用。在分泌性腺组织中，如乳腺，tj对于分离根尖和基底外侧结构域至关重要。TJs还创建可变屏障，通过上皮膜调节分子的细胞旁运动，从而维持组织稳态。最近的研究表明，TJs是由几种膜蛋白、细胞骨架蛋白和信号分子组成的大分子复合物。这些成分中的许多在乳腺发育和妊娠周期中受到调节，其中一些在乳腺癌进展过程中作为可能的“肿瘤抑制因子”受到了广泛关注。
Tight junctions (TJs), the most apical components of the cell-cell junctional complexes, play a crucial role in the establishment and maintenance of cell polarity within tissues. In secretory glandular tissues, such as the mammary gland, TJs are crucial for separating apical and basolateral domains. TJs also create the variable barrier regulating paracellular movement of molecules through epithelial sheets, thereby maintaining tissue homeostasis. Recent advances reveal that TJs exist as macromolecular complexes comprised of several types of membrane proteins, cytoskeletal proteins, and signaling molecules. Many of these components are regulated during mammary gland development and pregnancy cycles, and several have received much attention as possible "tumor suppressors" during progression to breast cancer.