Excess Gestational Weight Gain Modifying Fetal Macrosomia Risk Associated With Maternal Glucose
Excess Gestational Weight Gain Modifying Fetal Macrosomia Risk Associated With Maternal Glucose
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DOI：
10.1097/aog.0b013e31818a9779
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发表时间：
2008-11-01
影响因子：
7.2
通讯作者：
Pettitt, David J.
中科院分区：
文献类型：
--
作者：
Hillier, Teresa A.;Pedula, Kathryn L.;Pettitt, David J.
目的：为了评估孕妇体重增加和孕妇血糖与巨大儿风险（大于4，000 g）的关系，在普遍筛查妊娠期糖尿病（GDM）的人群中，方法：1995年至2003年，美国一个大型健康计划的两个地区（西北/夏威夷）的41，540名孕妇使用GDM筛查。50 g葡萄糖激发试验; 6，397人还接受了3小时100 g口服葡萄糖耐量试验。在校正了包括母亲年龄在内的潜在混杂因素后，我们评估了母亲血糖水平与血糖筛查和巨大儿风险之间的关系。新生儿的性别、种族和性别。我们根据母亲体重增加（40磅或更少与超过40磅相比）进行分层，因为过度的母亲体重增加会改变结果。
OBJECTIVE: To estimate how maternal weight gain and maternal glucose relate to fetal macrosomia risk (greater than 4,000 g) among a population universally screened for gestational diabetes mellitus (GDM).METHODS: Between 1995 and 2003, 41,540 pregnant women in two regions (Northwest/Hawaii) of a large U.S. health plan had GDM screening using the. 50-g glucose challenge test; 6,397 also underwent a 3-hour, 100-g oral glucose tolerance test. We assessed the relationship between level of maternal glucose with glucose screening and fetal macrosomia risk after adjustment for potential confounders, including maternal age,. parity, and ethnicity and sex of the newborn. We stratified by maternal weight gain (40 lb or fewer compared with more than 40 lb) because excessive maternal weight gain modified results.RESULTS: Among women with both normal and abnormal GDM screenings, increasing level of maternal glucose was linearly related to macrosomia risk (P