Prenatal exposure to fine particulate matter and birth weight: variations by particulate constituents and sources.
Prenatal exposure to fine particulate matter and birth weight: variations by particulate constituents and sources.
复制标题
DOI：
10.1097/ede.0b013e3181f2f405
复制
发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Leaderer BP
中科院分区：
文献类型：
--
作者：
Bell ML;Belanger K;Ebisu K;Gent JF;Lee HJ;Koutrakis P;Leaderer BP
孕期接触细颗粒物(PM2.5)与新生儿体重降低有关；然而，PM2.5的化学成分差异很大。PM2.5成分对健康的影响尚不清楚。我们调查了PM2.5的质量、成分和来源是否与足月出生体重有关。对2000年8月至2004年2月在康涅狄格州3个县和马萨诸塞州1个县收集的PM2.5过滤器进行了50多种元素的分析。源解析用于估计PM2.5源的日贡献，包括交通、道路灰尘/地壳、石油燃烧、盐分和区域(硫磺)源。对76,788名婴儿的孕期和三个月暴露于PM2.5的质量、成分和来源与出生体重和早产风险(足月出生和2500克)的关系进行了研究。道路粉尘和相关成分，如硅和铝，以及与机动车辆相关的元素碳和锌，以及与石油燃烧相关的元素钒和镍，都与较低的出生体重有关。四分位数范围的增加与出生体重较低的锌(风险增加12%)、元素碳(13%)、硅(10%)、铝(11%)、钒(8%)和镍(11%)有关。按三个月进行的分析显示，第三个月暴露于元素碳、镍、钒和燃油PM2.5的影响。孕妇暴露于来自特定来源的较高水平的PM2.5化学成分与较低的出生体重有关。
Exposure to fine particles (PM2.5) during pregnancy has been linked to lower birth weight; however, the chemical composition of PM2.5 varies widely. The health effects of PM2.5 constituents are unknown. We investigated whether PM2.5 mass, constituents, and sources are associated with birth weight for term births. PM2.5 filters collected in 3 Connecticut counties and 1 Massachusetts county from August 2000 through February 2004 were analyzed for more than 50 elements. Source apportionment was used to estimate daily contributions of PM2.5 sources, including traffic, road dust/crustal, oil combustion, salt, and regional (sulfur) sources. Gestational and trimester exposure to PM2.5 mass, constituents, and source contributions were examined in relation to birth weight and risk of small-at-term birth (term birth <2500 g) for 76,788 infants. Road dust and related constituents such as silicon and aluminum were associated with lower birth weight, as were the motor-vehicle-related species such as elemental carbon and zinc, and the oil-combustion-associated elements vanadium and nickel. An interquartile range increase in exposure was associated with low birthweight for zinc (12% increase in risk), elemental carbon (13%), silicon (10%), aluminum (11%), vanadium (8%), and nickel (11%). Analysis by trimester showed effects of third-trimester exposure to elemental carbon, nickel, vanadium, and oil-combustion PM2.5. Exposures of pregnant women to higher levels of certain PM2.5 chemical constituents originating from specific sources are associated with lower birth weight.