High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease
High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease
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DOI：
10.1016/j.neulet.2010.10.015
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发表时间：
2011-01-07
影响因子：
2.5
通讯作者：
Jose Marti, Maria
中科院分区：
文献类型：
--
作者：
Compta, Yaroslau;Ezquerra, Mario;Jose Marti, Maria
脑脊液（CSF） tau和磷酸化tau水平与阿尔茨海默病（AD）中某些tau基因变异和脑脊液淀粉样蛋白- β (A β)水平低相关，构成神经退行性变分子机制的潜在生物标志物。我们的目的是评估这些csf遗传内表型是否也存在于帕金森病（PD）中。采用特异性ELISA技术检测38例PD患者（其中19例伴痴呆）脑脊液中tau、phospho-tau和A β水平。所有病例均根据一系列tau基因多态性（rs1880753、rs1880756、rs1800547、rs1467967、rs242557、rs2471738和rs7521）进行基因分型。在显性和剂量反应模型下，a等位基因rs242557多态性是唯一与脑脊液tau和磷酸化tau水平升高显著相关的tau基因变异。这种关联依赖于痴呆的存在，并且仅在低(
Cerebrospinal fluid (CSF) tau and phospho-tau levels have been associated with certain tau gene variants and low CSF amyloid-beta (A beta) levels in Alzheimer disease (AD), constituting potential biomarkers of molecular mechanisms underlying neurodegeneration. We aimed to assess whether such CSF-genetic endophenotypes are also present in Parkinson disease (PD). CSF tau, phospho-tau and A beta levels were obtained from 38 PD patients (19 with dementia) using specific ELISA techniques. All cases were geno-typed for a series of tau gene polymorphisms (rs1880753, rs1880756, rs1800547, rs1467967, rs242557, rs2471738 and rs7521). The A-allele rs242557 polymorphism was the only tau gene variant significantly associated with higher CSF tau and phospho-tau levels, under both dominant and dose-response model. This association depended on the presence of dementia, and was only observed in individuals with low (