Value of Abdominal Susceptibility-Weighted Magnetic Resonance Imaging for Quantitative Assessment of Hepatic Iron Deposition in Patients with Chronic Hepatitis B: Comparison with Serum Iron Markers
Value of Abdominal Susceptibility-Weighted Magnetic Resonance Imaging for Quantitative Assessment of Hepatic Iron Deposition in Patients with Chronic Hepatitis B: Comparison with Serum Iron Markers
复制标题
DOI：
10.1177/147323001204000319
复制
发表时间：
2012-06
影响因子：
1.6
通讯作者：
Wenlv Lv;F. Yan;F. Yan;Mengsu Zeng;J. Zhang;Y. Yuan;J. Ma
中科院分区：
文献类型：
--
作者：
Wenlv Lv;F. Yan;F. Yan;Mengsu Zeng;J. Zhang;Y. Yuan;J. Ma
目的：利用腹部敏感性加权磁共振成像（SWI）定量评估慢性乙型肝炎（HBV）感染患者的肝铁沉积。方法：HBV感染患者和健康对照者进行腹部SWI，并评估血清铁标志物。测量了相值，并用SWI描述了肝铁沉积的五个等级。结果：前瞻性纳入了HBV感染患者（n = 327）和健康对照（n = 50）。通过SWI检测，总共有77例（25.4%）HBV感染患者存在肝铁沉积。有肝铁沉积的患者与无肝铁沉积的患者或对照组相值有显著差异，不同级别的肝铁沉积相值也有显著差异。肝铁沉积患者血清铁、铁蛋白、转铁蛋白和转铁蛋白饱和度明显高于无肝铁沉积患者。只有血清铁蛋白在不同程度的肝铁沉积中存在显著差异，且血清铁蛋白与相值呈低负相关。结论：与血清铁标志物相比，腹部SWI可能是定量评估慢性HBV感染患者肝铁沉积的有力工具。
OBJECTIVE: To assess hepatic iron deposition quantitatively in patients with chronic hepatitis B (HBV) infection, using abdominal susceptibility-weighted magnetic resonance imaging (SWI). METHODS: Patients with HBV infection and healthy controls underwent abdominal SWI and were assessed for serum iron markers. Phase values were measured and five grades of hepatic iron deposition were described by SWI. RESULTS: Patients with HBV infection (n = 327) and healthy controls (n = 50) were prospectively enrolled. In total, 77 (25.4%) patients with HBV infection had hepatic iron deposition as determined by SWI. Phase values were significantly different between patients with hepatic iron deposition compared with patients without hepatic iron deposition or controls, and were significantly different across different grades of hepatic iron deposition. Serum iron, ferritin, transferrin and transferrin saturation were significantly higher in patients with, versus those without, hepatic iron deposition. Only serum ferritin was significantly different across different grades of hepatic iron deposition, and there was a low inverse correlation between serum ferritin and phase values. CONCLUSIONS: Compared with serum iron markers, abdominal SWI may represent a powerful tool to assess hepatic iron deposition quantitatively in patients with chronic HBV infection.