Pioneer axon guidance by UNC-129, a C-elegans TGF-β
Pioneer axon guidance by UNC-129, a C-elegans TGF-β
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DOI：
10.1126/science.281.5377.706
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发表时间：
1998-07-31
期刊：
影响因子：
56.9
通讯作者：
Culotti, JG
中科院分区：
文献类型：
--
作者：
Colavita, A;Krishna, S;Culotti, JG
UNC-129基因和UNC-6 netrin基因一样，是引导秀丽线虫前驱运动轴沿着背腹轴运动的必需基因。UNC-129编码转化生长因子-β(TGF-β)分泌信号分子超家族的成员之一，在背侧而不是腹侧的体壁肌肉中表达。来自腹侧体壁肌肉的UNC-129的异位表达破坏了通常发生在背腹轴上的生长锥和细胞迁移。因此，在线虫中，UNC-129介导轴突引导和引导细胞迁移所需的背腹侧极性信息的表达。
The unc-129 gene, Like the unc-6 netrin gene, is required.to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.