MAGNETIC-RESONANCE IMAGING AND EXTRAPYRAMIDAL MOVEMENT-DISORDERS
MAGNETIC-RESONANCE IMAGING AND EXTRAPYRAMIDAL MOVEMENT-DISORDERS
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DOI：
10.1159/000116447
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发表时间：
1989-01-01
影响因子：
2.4
通讯作者：
DRAYER, BP
中科院分区：
文献类型：
--
作者：
DRAYER, BP
高场强磁共振成像是一种准确的临床技术，用于检测铁蛋白在脑中的相对分布。在正常成年人中，铁在苍白球，红核，黑质网状部和小脑齿状核中的浓度最高;其分布在T2加权图像上清晰地映射为信号低强度（黑暗），由于铁蛋白产生的局部场异质性。铁在出生时是缺乏的，在老年人的壳核中浓度增加。药物反应性差的帕金森病（多系统萎缩）的特征是壳核和尾状核中过早的信号低强度，而Hallervorden-Spatz病在儿童苍白球中表现出异常的低强度。运动障碍通常在与胶质增生相关的壳核中具有异常的高信号（白）。
High-field strength magnetic resonance imaging is an accurate clinical technique for detecting the relative distribution of ferritin in the brain. In normal adults, iron is found in highest concentrations in the globus pallidus, red nucleus, pars reticulata of the substantia nigra, and dentate nucleus of the cerebellum; its distribution is clearly mapped as signal hypointensity (darkness) on a T2-weighted image due to local-field heterogeneities produced by ferritin. Iron is absent at birth and increases in concentration in the putamen in the elderly. Poorly drug-responsive Parkinson''s disease (multiple-system atrophy) is characterized by premature signal hypointensity in the putamen and caudate, while Hallervorden-Spatz disease exhibits abnormal hypointensity in the globus pallidus in children. Dyskinetic disorders often have abnormal signal hyperintensity (whiteness) in the putamen related to gliosis.