Drinking in alcoholics following an alcohol challenge research protocol
Drinking in alcoholics following an alcohol challenge research protocol
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DOI：
10.15288/jsa.2000.61.220
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发表时间：
2000-03-01
期刊：
影响因子：
--
通讯作者：
Anton, RF
中科院分区：
文献类型：
--
作者：
Drobes, DJ;Anton, RF
目的：本研究探讨了参与酒精管理研究对25名非寻求治疗的酗酒者随后的饮酒行为的影响。方法：受试者参加了两次评估会议，随后是为期一周的三种药物（纳洛酮，纳美芬或安慰剂）之一的方案，为期一天的实验室评估，包括标准化的酒精管理程序，以及由个性化反馈和酒精咨询组成的汇报会议。随访包括酒精挑战会议后6周的电话采访。结果如下：在随访时，受试者报告饮酒量和频率较研究前显著减少，没有受试者报告参与研究后饮酒增加。结论：这些研究结果表明，酒精管理的研究程序可能不会对酗酒者的研究后饮酒行为有害。这种方法的使用可以谨慎地扩大，以提高对酒精中毒人群的研究结果的普遍性。
Objective: The present study examined the impact of participating in an alcohol administration study on the subsequent drinking behavior of 25 non-treatment-seeking alcoholics. Method: Subjects attended two assessment sessions, followed by a week-long regimen on one of three pharmacological agents (naltrexone, nalmefene, or placebo), a day-long laboratory assessment including a standardized alcohol administration procedure, and a debriefing session consisting of individualized feedback and alcohol counseling. Follow up consisted of a telephone interview 6 weeks after the alcohol challenge session. Results: At the follow-up interview, subjects reported significant reductions in drinking quantity and frequency from the prestudy period, and no subjects reported increased drinking following study participation. Conclusions: These findings suggest that alcohol administration research procedures may not be detrimental to the poststudy drinking behavior of alcoholics. The use of such procedures could he cautiously expanded to improve the generalizability of findings for alcoholic populations of interest.