Serum Reactive Oxygen Metabolite Levels Predict Severe Exacerbations of Asthma.
Serum Reactive Oxygen Metabolite Levels Predict Severe Exacerbations of Asthma.
复制标题
DOI：
10.1371/journal.pone.0164948
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Takizawa H
中科院分区：
文献类型：
--
作者：
Nakamoto K;Watanabe M;Sada M;Inui T;Nakamura M;Honda K;Wada H;Mikami Y;Matsuzaki H;Horie M;Noguchi S;Yamauchi Y;Koyama H;Kogane T;Kohyama T;Takizawa H
支气管哮喘（BA）是一种以气道高反应性和重塑为特征的慢性气道疾病，与慢性气道炎症密切相关。活性氧（ROS）如过氧化氢是由炎症细胞产生的，参与BA的发病机制。然而，ROS在BA患者治疗中的作用尚不清楚。我们试图确定ROS作为生物标志物在BA临床环境中的作用。我们从2013年到2015年招募了BA患者，研究哮喘控制程度、抗哮喘治疗、肺功能检查结果、呼气一氧化氮分数（FeNO）、血清活性氧代谢物（ROM）水平、血清白细胞介素(IL)-6和IL-8水平。我们招募了110例BA患者。血清ROM水平与白细胞（WBC）计数（rs = 0.273, p = 0.004）、中性粒细胞计数（rs = 0.235, p = 0.014）、CRP （rs = 0.403, p < 0.001）、IL-6 （rs = 0.339, p < 0.001）相关。血清ROM水平、IL-8、CRP水平与%FEV1呈负相关（rs = -0.240, p = 0.012, rs = -0.362, p < 0.001, rs = -0.197, p = 0.039）。3个月内出现严重加重的患者血清ROM水平显著高于未出现严重加重的患者（339 [302-381]vs. 376 [352-414], CARR U, p < 0.025）。受体-操作特征分析显示，ROM水平与严重加重的发生显著相关（曲线下面积：0.699,95% CI: 0.597-0.801, p = 0.025）。血清ROM水平与气道阻塞程度、白细胞计数、中性粒细胞计数、IL-6和严重恶化显著相关。该生物标志物可能有助于预测BA的严重恶化。
Bronchial asthma (BA) is a chronic airway disease characterized by airway hyperresponsiveness and remodeling, which are intimately linked to chronic airway inflammation. Reactive oxygen species (ROS) such as hydrogen peroxide are generated by inflammatory cells that are involved in the pathogenesis of BA. However, the role of ROS in the management of BA patients is not yet clear. We attempted to determine the role of ROS as a biomarker in the clinical setting of BA. We enrolled patients with BA from 2013 through 2015 and studied the degrees of asthma control, anti-asthma treatment, pulmonary function test results, fractional exhaled nitric oxide (FeNO), serum reactive oxygen metabolite (ROM) levels, and serum levels of interleukin (IL)-6 and IL-8. We recruited 110 patients with BA. Serum ROM levels correlated with white blood cell (WBC) count (rs = 0.273, p = 0.004), neutrophil count (rs = 0.235, p = 0.014), CRP (rs = 0.403, p < 0.001), and IL-6 (rs = 0.339, p < 0.001). Serum ROM levels and IL-8 and CRP levels negatively correlated with %FEV1 (rs = -0.240, p = 0.012, rs = -0.362, p < 0.001, rs = -0.197, p = 0.039, respectively). Serum ROM levels were significantly higher in patients who experienced severe exacerbation within 3 months than in patients who did not (339 [302–381] vs. 376 [352–414] CARR U, p < 0.025). Receiver-operating characteristics analysis showed that ROM levels correlated significantly with the occurrence of severe exacerbation (area under the curve: 0.699, 95% CI: 0.597–0.801, p = 0.025). Serum levels of ROM were significantly associated with the degrees of airway obstruction, WBC counts, neutrophil counts, IL-6, and severe exacerbations. This biomarker may be useful in predicting severe exacerbations of BA.
登录
查看更多内容
DOI：
10.1164/ajrccm.149.2.8306055
发表时间：
1994-02-01
影响因子：
24.7
作者：
HULSMANN, AR;RAATGEEP, HR;DEJONGSTE, JC
通讯作者：
DEJONGSTE, JC
影响因子：
10
作者：
Heijink, Irene;van Oosterhout, Antoon;van den Berge, Maarten
通讯作者：
van den Berge, Maarten
影响因子：
158.5
作者：
Corren, Jonathan;Lemanske, Robert F., Jr.;Matthews, John G.
通讯作者：
Matthews, John G.
DOI：
10.1164/ajrccm.161.5.9903006
发表时间：
2000-05-01
影响因子：
24.7
作者：
Fryer, AA;Bianco, A;Spiteri, MA
通讯作者：
Spiteri, MA
影响因子：
6.1
作者：
Lee, YL;Lin, YC;Guo, YL
通讯作者：
Guo, YL