Spontaneous elimination of hepatitis C virus RNA in individuals with persistent infection in a hyperendemic area of Japan
Spontaneous elimination of hepatitis C virus RNA in individuals with persistent infection in a hyperendemic area of Japan
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DOI：
10.1016/j.hepres.2005.10.004
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发表时间：
2006-01-01
影响因子：
4.2
通讯作者：
Tsubouchi, H
中科院分区：
文献类型：
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作者：
Uto, H;Hayashi, K;Tsubouchi, H
丙型肝炎病毒（HCV）携带者的自然病程尚不清楚。作为日本 HCV 高流行地区居民队列研究的一部分，我们检查了 HCV 自发消除个体的临床特征。在 1995 年被判定为持续性 HCV 感染的个体中，有 302 人在 1993 年至 2000 年间至少进行了 4 次年度 ALT 测量，并且未接受过 IFN 治疗。 2001 年和/或 2002 年对他们进行了 HCV RNA 检测，302 人中有 20 人未检测到 HCV RNA。在这20人中，7人被确认具有可检测到的HCV RNA，13人直到2000年才被确认。因此，2.4％（7/289）被判断为在那6年期间自发消除了HCV感染。尽管有或没有表现出自发消除的个体之间的年龄、性别、ALT水平或血清学定义的HCV基因型没有差异，但在1995年的测试中，HCV RNA的消除与低水平的HCVcAg (< 20 pg/mL) (P < 0.001)之间存在显着关系。这些结果表明，持续感染后HCV RNA的自发消除很少见，并且似乎与病毒载量有关。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
The natural course of hepatitis C virus (HCV) carriers is not well understood. We examined the clinical characteristics of individuals exhibiting spontaneous elimination of HCV as part of a cohort study of residents of a HCV hyperendemic area in Japan. In individuals who were judged to have persistent HCV infection in 1995, 302 had at least 4 annual ALT measurements between 1993 and 2000, and had not been treated with IFN. They were tested for the presence of HCV RNA in 2001 and/or 2002 and HCV RNA could not be detected in 20 of the 302 individuals. In these 20 individuals, 7 were confirmed to have detectable HCV RNA and 13 were not until 2000. Thus, 2.4% (7/289) were judged to have spontaneously eliminated the HCV infection during that 6-year period. Although there were no differences in age, sex, ALT levels, or serologically defined HCV genotype between individuals with and without exhibiting spontaneous elimination, there was a significant relationship between the elimination of HCV RNA and a low level of HCVcAg (< 20 pg/mL) (P < 0.001) upon testing in 1995. These results suggest that spontaneous elimination of HCV RNA following persistent infection is rare and appears to be related to viral load. (c) 2005 Elsevier Ireland Ltd. All rights reserved.