Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer
Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer
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DOI：
10.1158/1055-9965.epi-04-0688
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发表时间：
2005-05-01
影响因子：
3.8
通讯作者：
Kang, D
中科院分区：
文献类型：
--
作者：
Choi, JY;Lee, KM;Kang, D
我们检测了SULT1A1 （C . 779g > A、*14A > G和*85C > T）和SULT1E1 （IVS1-447C > A、IVS4-1653T > C和*959G > A）基因中常见的单核苷酸多态性（SNP）是否影响乳腺癌的风险和生存。我们的研究人群包括989名组织学证实的散发性乳腺癌患者和1054名无癌症病史的对照组，这些患者来自首尔的三家教学医院。采用logistic回归模型估计比值比（OR）和95%置信区间（95% CD）。在529例完成治疗的乳腺癌患者的生存分析中，采用Cox比例风险模型计算风险比（HR）。与GG基因型相比，SULT1E1 *959 GA/AA基因型的女性患乳腺癌的风险中度降低（OR, 0.8; 95% CI, 0.70-1.00）。考虑单倍型时，与野生型CTG-CTG单倍型相比，纯合子*959 AA基因型与IVS4-1653 T - > C碱基变化（CTA-CCA单倍型）的乳腺癌风险降低一半（OR为0.5；95% CI为0.24-0.88）。在SULT1A1和SULT1E1 snp或单倍型与乳腺癌风险之间没有观察到其他显著的总体关联。当按生存期分层时，SULT1E1 IVS4-1653 TC/CC基因型患者的复发风险是TT基因型患者的3倍（HR, 3.2; 95% CI, 1.39-7.48）。此外，当考虑单倍型时，SULT1E1 *959 G > A碱基变化与IVS4-1653 T > C碱基变化（CTG-CCA单倍型）与> 4倍乳腺癌风险相关（OR, 4.2; 95% CI, 1.15-15.15）。这些发现表明，SULT1E1基因多态性与韩国女性乳腺癌风险增加和无病生存有关。
We examined whether common single nucleotide polymorphisms (SNP) in SULT1A1 (c.779G > A, *14A > G, and *85C > T) and SULT1E1 (IVS1-447C > A, IVS4-1653T > C, and *959G > A) genes influenced the risk and survival of breast cancer. Our study population consisted of 989 histologically confirmed sporadic breast cancer patients and 1,054 controls without history of cancer recruited from three teaching hospitals in Seoul. Odds ratios (OR) and 95% confidence intervals (95% CD were estimated by logistic regression model. In the survival analysis for 529 breast cancer patients with completed treatments, the hazard ratios (HR) were calculated with Cox proportional hazard model. Women with the SULT1E1 *959 GA/AA genotype had a moderately decreased breast cancer risk compared with those with the GG genotypes (OR, 0.8; 95% CI, 0.70-1.00). When the haplotypes were considered, the homozygous *959 AA genotype together with the IVS4-1653 T > C base change (CTA-CCA haplotype) was associated with halved breast cancer risk (OR, 0.5; 95% CI, 0.24-0.88) compared with the wild type CTG-CTG haplotype. No other significant overall association was observed between the SULT1A1 and SULT1E1 SNPs nor haplotypes and breast cancer risk. When stratified by survival, patients with the SULT1E1 IVS4-1653 TC/CC genotypes showed a > 3-fold risk of recurrence (HR, 3.2; 95% CI, 1.39-7.48) compared with those with the TT genotype. Moreover, when the haplotypes were considered, the SULT1E1 *959 G > A base change together with the IVS4-1653 T > C base change (CTG-CCA haplotype) was associated with a > 4-fold risk of breast cancer (OR, 4.2; 95% CI, 1.15-15.15). These findings suggest that genetic polymorphisms of SULT1E1 are associated with increased risk and a disease free survival of breast cancer in Korean women.