Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse.
Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse.
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人、大鼠和小鼠之间 p53 和 miR-138 的物种特异性相互调节
DOI：
10.1038/srep26187
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发表时间：
2016-05-17
影响因子：
4.6
通讯作者：
Shao N
中科院分区：
文献类型：
--
作者：
Li J;Xia W;Su X;Qin X;Chen Y;Li S;Dong J;Ding H;Li H;Huang A;Ge X;Hou L;Wang C;Sun L;Bai C;Shen X;Fang T;Liu Y;Zhang Y;Zhang H;Zhang H;Shao N
近年来，p53被鉴定为调节许多miRNAs的表达，并且也受到miRNAs的调节。在这篇论文中，我们发现miR-138在人非小细胞肺癌（NSCLC）细胞中p53激活后表现出明显的增加，这是由其宿主基因启动子区的p53结合位点介导的，但在大鼠和小鼠细胞中没有发生这种情况。更有趣的是，我们发现p53在小鼠和大鼠细胞中也可以受到miR-138的调控，但在人类NSCLC细胞中则不然。我们的研究结果表明，存在的物种特异性差异的调节miRNA针对其目标和调节miRNA本身的其他蛋白质。
In recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the promoter region of its host gene, but this did not happen with rat and mouse cells. More interestingly, we found that p53 could be also regulated by miR-138 in mouse and rat cells, but not in the human NSCLC cells. Our results suggest the existence of species-specific differences of the regulations of miRNA against its targets and the regulations of miRNA itself by other proteins.