Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain?
Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain?
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DOI：
10.2337/db16-1444
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发表时间：
2017-07-01
期刊：
影响因子：
7.7
通讯作者：
Henriksen, Kim
中科院分区：
文献类型：
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作者：
Neergaard, Jesper S.;Dragsbaek, Katrine;Henriksen, Kim
痴呆症和 2 型糖尿病的特点都是前驱期较长，这给潜在危险因素及其时间关系的研究带来了挑战。代谢综合征、胰岛素抵抗 (IR) 和痴呆之间的渐进关系最近受到质疑，因此本研究的目的是评估这些 2 型糖尿病前兆和认知功能障碍之间的潜在关联。使用前瞻性流行病学危险因素 (PERF) 研究（n = 2,103）（一项针对丹麦老年妇女的前瞻性研究）的数据，我们发现空腹血糖浓度受损与认知功能障碍的可能性增加 44% (9-91%) 相关。此外，高于 HOMA-IR 阈值 (HOMA-IR >2.6) 的受试者出现认知功能障碍的几率要高出 47% (9-99%)。这些关联可能表明，通过有效预防和控制胰岛素稳态，很大一部分女性痴呆病例可能是可以预防的。
Dementia and type 2 diabetes are both characterized by long prodromal phases, challenging the study of potential risk factors and their temporal relation. The progressive relation among metabolic syndrome, insulin resistance (IR), and dementia has recently been questioned, wherefore the aim of this study was to assess the potential association among these precursors of type 2 diabetes and cognitive dysfunction. Using data from the Prospective Epidemiological Risk Factor (PERF) Study (n = 2,103), a prospective study of elderly women in Denmark, we found that impaired fasting plasma glucose concentration was associated with 44% (9-91%) larger probability of cognitive dysfunction. In addition, subjects above the HOMA-IR threshold (HOMA-IR >2.6) had 47% (9-99%) larger odds of cognitive dysfunction. The associations could indicate that a significant proportion of dementia cases in women is likely to be preventable by effective prevention and control of the insulin homeostasis.