Albendazole and mebendazole have low efficacy against Trichuris trichiura in school-age children in Kabale District, Uganda
Albendazole and mebendazole have low efficacy against Trichuris trichiura in school-age children in Kabale District, Uganda
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DOI：
10.1016/j.trstmh.2008.12.010
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发表时间：
2009-05-01
影响因子：
2.2
通讯作者：
Thamsborg, Stig M.
中科院分区：
文献类型：
--
作者：
Olsen, Annette;Namwanje, Harriet;Thamsborg, Stig M.
3组感染鞭虫的学龄期儿童分别用丙硫咪唑400 mg、甲苯咪唑100 mg、2次/d、3 cl/d或甲苯咪唑100 mg、2次/d、5 d/d治疗。阿苯达唑研究调查了治愈率和减蛋率，发现66名感染儿童中只有5名在治疗后7天为鸡蛋阴性，治愈率为8%，几何平均减蛋率为89%。然而，在治疗后第14天，所有儿童再次出现虫卵阳性，虫卵计数显著高于第7天（P < 0.001）。两项甲苯咪唑研究旨在恢复成年T。蠕虫甲苯咪唑治疗3 d后，34例感染儿童中有2例在治疗开始后3-5 d仅回收4条蠕虫。用甲苯咪唑治疗5d后，21例患儿中有10例排出虫体27条。在最后一种情况下，第一条蠕虫在给药后第4天出现，并且在研究结束时第7天回收的蠕虫数量最多。总之，即使采用最长的治疗方案并连续7天收集粪便样本，也仅回收很少的蠕虫。本研究的结果表明，替代药物和/或替代方案，在目前的控制计划，对T。须再次引起注意。(C)2009年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
Three groups of Trichuris trichiura-infected school-age children were treated with one dose 400 mg albendazole, 100 mg mebendazole twice daily for 3 cl, or 100 mg mebendazole twice daily for 5 d. The albendazole study investigated cure and egg reduction rates and found that only 5 of 66 infected children were egg-negative 7 d post-treatment, giving a cure rate of 8% and a geometric mean egg reduction rate of 89%. However, at day 14 post-treatment, all children were again egg-positive with significantly higher egg counts than at day 7 (P < 0.001). The two mebendazole studies aimed for the recovery of adult T. trichiura worms. After the 3 d course of mebendazole treatment, only four worms were recovered on days 3-5 after start of treatment from 2 of 34 infected children. With the 5 d course of mebendazole treatment, 10 of 21 infected children expelled a total of 27 worms. In the last case the first worm appeared on day 4 post-treatment, and the highest number of worms was recovered when the study ended at day 7. In conclusion, even with the longest treatment regimen and collecting stool samples over seven consecutive days, only very few worms were recovered. The results of this study suggest that alternative drugs and/or alternative regimens in current control programmes against T. trichiura need renewed attention. (C) 2009 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.