Characterization of the cellular immune response in hepatitis C virus infection.
Characterization of the cellular immune response in hepatitis C virus infection.
复制标题
丙型肝炎病毒感染中细胞免疫反应的特征。
DOI：
10.1002/med.20157
复制
发表时间：
2009
影响因子：
13.3
通讯作者：
Germann,MarkusW
中科院分区：
文献类型：
--
作者：
Zhang,Xinjian;Dou,Jun;Germann,MarkusW
丙型肝炎病毒（HCV）是一种嗜肝RNA病毒，是慢性肝炎、肝硬化和肝细胞癌的主要病原体。宿主免疫反应，特别是细胞免疫反应，在病毒清除、肝损伤和持续性HCV感染中起重要作用。HCV细胞免疫反应的全面表征对于理解宿主免疫系统和病毒成分之间的相互作用以及开发有效的治疗和预防HCV疫苗非常重要。本文综述了最近的研究进展，以更好地理解HCV感染中的细胞免疫反应。©2009 Wiley期刊公司医学研究，29,No. 6, 843-866, 2009
Hepatitis C virus (HCV), a hepatotropic RNA virus, is a major causative agent of chronic hepatitis, liver cirrhosis, and hepatocellular carcinomas. The host immune responses, especially cellular immune responses, play an important role in viral clearance, liver injury, and persistent HCV infection. A thorough characterization of the HCV cellular immune responses is important for understanding the interplays between host immune system and viral components, as well as for developing effective therapeutic and prophylactic HCV vaccines. Recent advances that provide better understanding the cell immune responses in HCV infection are summarized in this article. © 2009 Wiley Periodicals, Inc. Med Res Rev, 29, No. 6, 843–866, 2009