Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma.
Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma.
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WNT-1对口腔鳞状细胞癌β-catenin表达的影响及其与Ki-67和肿瘤分化的关系。
DOI：
10.3892/or.13.6.1095
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发表时间：
2005
期刊：
影响因子：
4.2
通讯作者：
G. Yan
中科院分区：
文献类型：
--
作者：
Wei;L. Lo Muzio;C. Rubini;G. Yan
WNT-1已被证明在某些癌症的发生中起重要作用，但其在口腔鳞状细胞癌（OSCC）中的意义尚未阐明。我们研究了WNT-1在口腔鳞状细胞癌中的表达，其对β-catenin表达的作用及其与Ki-67和肿瘤分化的关系。采用免疫组化方法检测82例口腔鳞癌手术标本中WNT-1、β-catenin、E-cadherin、γ-catenin和Ki-67的表达。将结果与临床病理资料进行比较，并将其相关性进行分析。WNT-1低表达39例，中表达5例，高表达38例。WNT-1与β-catenin、E-cadherin、gamma-catenin和Ki-67的表达显著相关。与肿瘤分化程度显著相关。本研究结果表明，WNT-1的表达与β-catenin、Ki-67及肿瘤分化程度相关，提示WNT-1可能在口腔鳞癌发生过程中分化紊乱和增殖失控中起重要作用。
WNT-1 has been demonstrated to play an important role in the carcinogenesis of some cancers, but its significance in oral squamous cell carcinoma (OSCC) has not yet been elucidated. We investigated the WNT-1 expression in OSCC, its role on the expression of beta-catenin and its relation to Ki-67 and tumor differentiation. Surgical specimens from 82 OSCC patients were examined for WNT-1, beta-catenin, E-cadherin, gamma-catenin and Ki-67 expression by immunohistochemical staining. The results were compared with the clinicopathological data and the relationships were correlated. WNT-1 expression was low in 39 cases, moderate in 5 cases, and high in 38 cases. WNT-1 showed a significant association with the expression of beta-catenin, E-cadherin, gamma-catenin and Ki-67. It was significantly correlated with tumor differentiation. The results of this study showed that WNT-1 expression is correlated with beta-catenin, Ki-67 and tumor differentiation, which suggested that WNT-1 might play an important role in the disturbed differentiation and uncontrolled proliferation during OSCC carcinogenesis.