Estrogen Carcinogenesis in Breast Cancer
Estrogen Carcinogenesis in Breast Cancer
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DOI：
10.1016/j.ecl.2011.05.009
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发表时间：
2011-09-01
影响因子：
4.5
通讯作者：
Germain, Doris
中科院分区：
文献类型：
--
作者：
Germain, Doris
许多研究已经报道了雌激素水平升高与乳腺癌之间的相关性，这一观察结果引发了关于激素替代疗法长期使用的争议。这篇综述不会进一步讨论这一有争议的话题；相反，这篇综述主要集中在雌激素信号在乳腺正常发育中的作用，以及第二，该信号通路的改变如何导致乳腺癌。
Many studies have reported a correlation between elevated estrogen blood levels and breast cancer and this observation has raised controversy concerning the long-term use of hormonal replacement therapy. This review will not address further this controversial topic; but rather, this review focuses on the role of estrogen signaling in first, the normal development of the breast and second, how alterations of this signaling pathway contribute to breast cancer.