Assessment of the Epidemic Potential of a New Strain of Rotavirus Associated with the Novel G9 Serotype Which Caused an Outbreak in the United States for the First Time in the 1995-1996 Season
Assessment of the Epidemic Potential of a New Strain of Rotavirus Associated with the Novel G9 Serotype Which Caused an Outbreak in the United States for the First Time in the 1995-1996 Season
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1995-1996年季节在美国首次爆发的与新型G9血清型相关的轮状病毒新株的流行潜力评估
DOI：
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发表时间：
2004
影响因子：
9.4
通讯作者：
J. Gentsch
中科院分区：
文献类型：
--
作者：
H. Clark;D. Lawley;A. Schaffer;Janice M Patacsil;A. Marcello;R. Glass;Vivek Jain;J. Gentsch
轮状病毒在发达国家引起严重的发病率，在欠发达国家引起频繁的死亡（每年≥ 50万人）。历史上，四种血清型-G1、G2、G3和G4-占主导地位;它们由两种表面中和抗原（VP 7）之一区分。然而，在1983年和1984年，我们描述了一种新的轮状病毒血清型，命名为G9，在费城，宾夕法尼亚州住院腹泻的五名儿童。G9轮状病毒在西半球没有被再次发现，直到它引起约。1995-1996年季节在费城检测到的轮状病毒病的50%。这次爆发使我们怀疑一个完全新的轮状病毒株是否会针对非常年幼的婴儿或年龄较大的儿童，导致特别严重的疾病，或完全取代以前存在的血清型。我们观察到在较年幼的婴儿中（特别是在那些<6个月大的婴儿中）G9感染显著过量，这可能归因于母亲中缺乏G9特异性抗体。值得进一步注意的是，7名年龄最大的轮状病毒腹泻患者中有6名感染了G9菌株（不显著）。然而，在5年的研究期间，无论感染血清型如何，轮状病毒儿童的年龄分布没有差异。与G9菌株相关的腹泻患者没有比G1，G2或G3血清型引起的疾病更严重。G9株没有取代其他血清型，但在随后的三个轮状病毒季节几乎完全被G1或G2血清型取代。我们的结论是，这种新的轮状病毒血清型的突然出现并没有对社区的公共卫生构成特别的威胁。
ABSTRACT Rotavirus causes severe morbidity in developed countries and frequent deaths (≥500,000 per year) in less-developed countries. Historically, four serotypes—G1, G2, G3, and G4—have predominated; they are distinguished by one of two surface neutralization antigens (VP7). However, in 1983 and 1984 we described a new rotavirus serotype, designated G9, in five children hospitalized for diarrhea in Philadelphia, Pa. G9 rotavirus was not identified again in the Western Hemisphere until it caused ca. 50% of the rotavirus disease detected in Philadelphia in the 1995-1996 season. This outbreak allowed us to question whether a rotavirus strain completely new to a well-studied community would target either very young infants or older children, cause especially severe disease, or completely displace previously extant serotypes. We observed a significant excess of G9 infections in younger infants (especially in those <6 months old) that might be attributed to the lack of G9-specific antibodies in mothers. Of further note, six of the seven oldest patients with rotavirus diarrhea were infected with the G9 strains (not significant). However, the age distribution of children with rotavirus did not differ over a 5-year study period regardless of the infecting serotype. Patients with diarrhea associated with G9 strains did not have disease more severe than that caused by the G1, G2, or G3 serotype. G9 strains did not displace the other serotypes but were virtually completely replaced by G1 or G2 serotypes in the three subsequent rotavirus seasons. We conclude that the abrupt appearance of this novel rotavirus serotype did not present a special threat to public health in the community.
儿童 WC3 重配疫苗。
DOI：
10.1007/978-3-7091-6553-9_20
发表时间：
1996
期刊：
Archives of virology. Supplementum
影响因子：
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作者：
Clark,HF;Offit,PA;Ellis,RW;Krah,D;Shaw,AR;Eiden,JJ;Pichichero,M;Treanor,JJ
通讯作者：
Treanor,JJ
G9血清型轮状病毒株VP7基因多态性及其对PCR检测G基因型的影响
影响因子：
5
作者：
Santos,Norma;Volotao,EduardoM;Soares,CarolineC;Albuquerque,MariaCarolinaM;daSilva,FabianoM;Chizhikov,Vladimir;Hoshino,Yasutaka
通讯作者：
Hoshino,Yasutaka