Chemotherapy in non-small cell lung cancer.
Chemotherapy in non-small cell lung cancer.
复制标题
非小细胞肺癌的化疗。
DOI：
10.1093/annonc/6.suppl_1.s83
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
H. Anderson
中科院分区：
文献类型：
--
作者：
N. Thatcher;M. Ranson;S. Lee;R. Niven;H. Anderson
背景
非小细胞肺癌不能再被视为化疗耐药，最近在旧药物的使用方面有了相当大的改进，在新药识别方面也取得了进展。最近的荟萃分析也证实了这样的观点，即化疗可以有微小但适度的生存益处。虽然在IV期疾病的治疗中，疗效标准主要集中在肿瘤应答率上，但最近很明显，这些患者也可以在改善症状控制方面受益。
最新进展
对于局部晚期III期疾病的患者，已经有了重要的进展，表明了联合化疗和胸部放射治疗的好处。此外，新辅助化疗的使用表明，大约一半的患者可以切除，15%-20%的切除标本的病理检查没有残留肿瘤的证据。这些结果证明在这种疾病中增加全身化疗的使用是合理的。
BACKGROUND
Non-small cell lung cancer can no longer be regarded as resistant to chemotherapy, and there have recently been considerable improvements in the use of the older agents and advances in the identification of new drugs. Recent meta-analysis has also confirmed the view that chemotherapy can have small but modest survival benefits. Although in the treatment of stage IV disease the criteria of efficacy have concentrated on tumour response rates, more recently it has become obvious that these patients can also benefit in terms of improved symptom control.
RECENT ADVANCES
For patients with locally advanced stage III disease there have been important developments indicating the benefit of combined modality treatment with chemotherapy and thoracic irradiation. Furthermore, the use of neoadjuvant chemotherapy indicates that resection is possible in about half the patients, and on pathological examination of 15%-20% of the resected specimens there is no evidence of residual tumour. These results justify an increase in the use of systemic chemotherapy in this disease.
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交替联合化疗对肺转移性大细胞癌和腺癌门诊患者生存的影响。
DOI：
10.1200/jco.1986.4.4.502
发表时间：
1986
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Miller,TP;Chen,TT;ColtmanJr,CA;O'Bryan,RM;Vance,RB;Weiss,GB;Fletcher,WS;Stephens,RL;Livingston,RB
通讯作者：
Livingston,RB
DOI：
10.1016/s0959-8049(05)80140-6
发表时间：
1993
期刊：
European journal of cancer (Oxford, England : 1990)
影响因子：
--
作者：
Weitberg,AB;Yashar,J;Glicksman,AS;Posner,M;Cummings,F;Browne,M;Clark,J;Calabresi,P;Beitz,J;Murray,C
通讯作者：
Murray,C
影响因子：
158.5
作者：
DILLMAN, RO;SEAGREN, SL;GREEN, MR
通讯作者：
GREEN, MR
DOI：
10.1016/s0022-5223(19)33853-x
发表时间：
1993-01-01
影响因子：
6
作者：
RUSCH, VW;ALBAIN, KS;BENFIELD, JR
通讯作者：
BENFIELD, JR
影响因子：
45.3
作者：
OCONNELL, JP;KRIS, MG;GOLBEY, RB
通讯作者：
GOLBEY, RB