Mechanistic modelling of avascular tumor growth and pharmacokinetics influence - Part I
Mechanistic modelling of avascular tumor growth and pharmacokinetics influence - Part I
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DOI：
10.1016/j.ces.2006.12.010
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发表时间：
2007-04-01
影响因子：
4.7
通讯作者：
Masi, Maurizio
中科院分区：
文献类型：
--
作者：
Busini, Valentina;Arosio, Paolo;Masi, Maurizio
这里介绍了“体内”和“体外”条件中的血管肿瘤生长的机械模型。它涉及主细胞生理，例如生长（通过底物摄取），有丝分裂，凋亡和坏死，所有这些都及其相应的动力学。通过时刻的方法解决了由此产生的人口平衡。此外，该模型与药代动力学的经典方程组合在一起，以考虑影响细胞坏死动力学或生长动力学的活性药物。将该模型与文献肿瘤生长数据进行了比较，既可以体内和体外条件。 （c）2007 Elsevier Ltd.保留所有权利。
A mechanistic model for the avascular tumor growth both for in "in vivo" and "in vitro" conditions is presented here. It involves the main cell physiology, like the growth (by substrate uptake), the mitosis, the apoptosis and the necrosis, all with their corresponding kinetics. The resulting population balance was solved through the moments' method. Moreover, the model was combined with the classic equations of pharmacokinetics to consider also the presence of active drugs affecting either the kinetics of cell necrosis or growth. The model was compared with literature tumor growth data both for in vivo and in vitro conditions. (c) 2007 Elsevier Ltd. All rights reserved.