Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo.
Statistical hemodynamics: a tool for evaluating the effect of fluid dynamic forces on vascular biology in vivo.
复制标题
统计血流动力学：评估流体动力对体内血管生物学影响的工具。
DOI：
10.1115/1.2354212
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
LaMack,JeffreyA
中科院分区：
文献类型：
--
作者：
Friedman,MortonH;Himburg,HeatherA;LaMack,JeffreyA
BackgroundIn vivo experimentation is the most realistic approach for exploring the vascular biological response to the hemodynamic stresses that are present in life. Post-mortem vascular casting has been used to define the in vivo geometry for hemodynamic simulation; however, this procedure damages or destroys the tissue and cells on which biological assays are to be performed.Method of ApproachTwo statistical approaches, regional (RSH) and linear (LSH) statistical hemodynamics, are proposed and illustrated, in which flow simulations from one series of experiments are used to define a best estimate of the hemodynamic environment in a second series. As an illustration of the technique, RSH is used to compare the gene expression profiles of regions of the proximal external iliac arteries of swine exposed to different levels of time-average shear stress.ResultsThe results indicate that higher shears promote a more atheroprotective expression phenotype in porcine arterial endothelium.ConclusionStatistical hemodynamics provides a realistic estimate of the hemodynamic stress on vascular tissue that can be correlated against biological response.
