Severe complicated neutropenia in two patients with metastatic non-small-cell lung cancer treated with nivolumab
Severe complicated neutropenia in two patients with metastatic non-small-cell lung cancer treated with nivolumab
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DOI：
10.1097/cad.0000000000000520
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发表时间：
2017-08-01
影响因子：
2.3
通讯作者：
Bar-Sela, Gil
中科院分区：
文献类型：
--
作者：
Turgeman, Ilit;Wollner, Mira;Bar-Sela, Gil
Checkpoint inhibitors effectively enhance the natural immune response against cancer, but they are also known to induce a unique spectrum of immune-related adverse events. Here, we report the first case of isolated neutropenia subsequent to nivolumab therapy. Prominent activated T-cells were found in the patient's serum and bone marrow alongside evidence of maturational defects in neutrophil precursors. Antineutrophil antibodies were not detected despite reliable testing techniques. A T-cell-mediated response is probable, consistent with the established mechanism for the development of other immune-related toxicities. Awareness of this rare and severe side effect reinforces the importance of early diagnosis and prompt initiation of proper treatment.
