Football's InfluencE on Lifelong health and Dementia risk (FIELD): protocol for a retrospective cohort study of former professional footballers
Football's InfluencE on Lifelong health and Dementia risk (FIELD): protocol for a retrospective cohort study of former professional footballers
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DOI：
10.1136/bmjopen-2018-028654
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发表时间：
2019-05-01
期刊：
影响因子：
2.9
通讯作者：
Stewart, William
中科院分区：
文献类型：
--
作者：
Russell, Emma R.;Stewart, Katy;Stewart, William
简介 在过去的十年中，有证据表明参与接触性运动与晚期神经退行性疾病（特别是慢性创伤性脑病）风险增加之间存在潜在联系。尽管仍然缺乏明确的证据来检验参与接触性运动与痴呆症发病率增加有关的假设，但公众对该风险的担忧日益增加。因此，迫切需要进行研究，以更好地了解参与接触性运动所涉及的潜在风险，并将这些风险与运动的整体健康益处联系起来。方法和分析足球对终身健康和痴呆症风险的影响被设计为一项回顾性队列研究，旨在分析前职业足球运动员（FPF）的数据，以评估该人群神经退行性疾病的发病率。将分析全面的电子医疗和死亡记录，并将其与人口统计匹配的人口控制队列的记录进行比较。除了神经退行性疾病的发病率之外，还将分析全因死亡率和疾病特异性死亡率，以评估终身健康状况。将运行 Cox 比例风险模型，将从 FPF 收集的数据与匹配的人群对照进行比较。 伦理与传播 研究已获得格拉斯哥大学医学、兽医和生命科学研究伦理委员会（项目编号 200160147）和国家卫生服务苏格兰公共福利和隐私小组（申请号 1718-0120）的批准。
Introduction In the past decade, evidence has emerged suggesting a potential link between contact sport participation and increased risk of late neurodegenerative disease, in particular chronic traumatic encephalopathy. While there remains a lack of clear evidence to test the hypothesis that contact sport participation is linked to an increased incidence of dementia, there is growing public concern regarding the risk. There is, therefore, a pressing need for research to gain greater understanding of the potential risks involved in contact sports participation, and to contextualise these within holistic health benefits of sport.Methods and analysis Football's InfluencE on Lifelong health and Dementia risk is designed as a retrospective cohort study, with the aim to analyse data from former professional footballers (FPF) in order to assess the incidence of neurodegenerative disease in this population. Comprehensive electronic medical and death records will be analysed and compared with those of a demographically matched population control cohort. As well as neurodegenerative disease incidence, all-cause, and disease-specific mortality, will be analysed in order to assess lifelong health. Cox proportional hazards models will be run to compare the data collected from FPFs to matched population controls.Ethics and dissemination Approvals for study have been obtained from the University of Glasgow College of Medical, Veterinary and Life Sciences Research Ethics Committee (Project Number 200160147) and from National Health Service Scotland's Public Benefits and Privacy Panel (Application 1718-0120).