Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer's disease
Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer's disease
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DOI：
10.1007/s00259-012-2088-x
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发表时间：
2012-06-01
影响因子：
9.1
通讯作者：
Rowe, Christopher C.
中科院分区：
文献类型：
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作者：
Villemagne, Victor L.;Mulligan, Rachel S.;Rowe, Christopher C.
用F-18标记的放射性示踪剂的淀粉样蛋白成像将允许广泛使用该技术，促进阿尔茨海默病（AD）的研究、诊断和治疗开发。本分析的目的是比较接受C-11-PiB（PiB）和F-18-florbetaben（FBB）PET成像的受试者的皮质A β沉积数据，我们确定了10名健康老年人对照（HC）和10名AD患者，他们在静脉注射370 MBq的PiB和300 MBq的FBB后接受PET成像。将PiB和FBB图像共配准，以使两次扫描中感兴趣区域的位置相同，并在注射PiB和FBB后40 - 70 min和90 - 110 min之间使用小脑皮质作为参考区域计算标准摄取值比率（SUVR），当使用两种放射性示踪剂与HC相比时，在AD患者中观察到在大多数皮质区域中显著更高的SUVR值（p < 0.0001）。AD患者的总体SUVR值平均比HC患者高75%（PiB）和56%（FBB）。PiB和FBB总体SUVR值之间存在极好的线性相关性（r = 0.97，p < 0.0001），对于两种放射性示踪剂，具有用于区分AD与HC受试者的相似的效应量（对于PiB，Cohen的d为3.3，对于FBB，Cohen的d为3.0）JBB虽然具有比PiB更窄的动态范围，但清楚地区分HC与AD患者，具有相当的效应量。FBB似乎是一个合适的F-18放射性示踪剂成像AD病理在体内。
Amyloid imaging with F-18-labelled radiotracers will allow widespread use of this technique, facilitating research, diagnosis and therapeutic development for Alzheimer's disease (AD). The purpose of this analysis was to compare data on cortical A beta deposition in subjects who had undergone both C-11-PiB (PiB) and F-18-florbetaben (FBB) PET imaging.We identified ten healthy elderly controls (HC) and ten patients with AD who had undergone PET imaging after intravenous injection of 370 MBq of PiB and 300 MBq of FBB under separate research protocols. PiB and FBB images were coregistered so that placement of regions of interest was identical on both scans and standard uptake value ratios (SUVR) using the cerebellar cortex as reference region were calculated between 40 and 70 min and between 90 and 110 min after injection for PiB and FBB, respectively.Significantly higher SUVR values (p < 0.0001) in most cortical areas were observed in AD patients when compared with HC with both radiotracers. Global SUVR values in AD patients were on average 75% higher than in HC with PiB and 56% higher with FBB. There was an excellent linear correlation between PiB and FBB global SUVR values (r = 0.97, p < 0.0001) with similar effect sizes for distinguishing AD from HC subjects for both radiotracers (Cohen's d 3.3 for PiB and 3.0 for FBB).FBB, while having a narrower dynamic range than PiB, clearly distinguished HC from AD patients, with a comparable effect size. FBB seems a suitable F-18 radiotracer for imaging AD pathology in vivo.